Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ACYP1 Antibody (2-RE16) is a high quality monoclonal ACYP1 antibody (also designated ACYP1 antibody) suitable for the detection of the ACYP1 protein of human origin. ACYP1 Antibody (2-RE16) is available as the non-conjugated anti-ACYP1 antibody. Acylphophatase is a cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two acylphophatase isoenzymes exist: ACYP1, also known as erythrocyte acylphosphatase, and ACYP2, also known as muscle acylphosphatase. The two isoenzymes share 60% homology and have the same substrate specificity, although ACYP1 has higher catalytic activity than ACYP2. ACYP2 has emerged as a significant model system to study protein misfolding and aggregation. It is particularly suitable for these studies because ACYP2 is a small, simple protein of only 98 amino acids consisting of a five-stranded antiparallel b-sheet and two parallel a-helices. Mutations in ACYP2 between residues 16-31 and 87-98, which includes its phosphate binding site at Arg-23, significantly increase the rate of aggregation. These mutations correlate with changes in the hydrophobicity of ACYP2 and a conversion of the a-helical structures to b-sheets. Therefore, a reduction in the net charge of a protein may be a key determinant in some forms of protein deposition diseases.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with ACYP1 (2-RE16): sc-134246 antibody?
Asked by: DefinitelyNotMatt
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.