Date published: 2025-9-8

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ACBD3 抗体 (518): sc-101277

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说明书
  • ACBD3 抗体 518 是小鼠单克隆 IgG1 κ,ACBD3抗体, 在15篇文献中引用,规格为100 µg/ml
  • 针对氨基酸 73-172 产生 ACBD3 的部分片段,来自 human
  • 推荐用于 mouse, rat 和 human 来源的ACBD3 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取ACBD3 (518): sc-101277免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 ACBD3 抗体 (518) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与ACBD3 抗体 (518) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

ACBD3抗体(518)是一种IgG1κ小鼠单克隆ACBD3抗体(也称为ACBD3抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的ACBD3蛋白。ACBD3抗体(518)可作为非偶联的抗ACBD3抗体。ACBD3(含酰基辅酶A结合结构域的蛋白3),也称为GCP60(高尔基体驻留蛋白GCP60)、GOCAP1、PAP7或GOLPH1,是一种高尔基体膜蛋白,含有一个ACB(酰基辅酶A结合)结构域和一个GOLD(高尔基体动力学)结构域,这对它与其他蛋白质的相互作用至关重要。ACBD3在卵巢和睾丸中广泛表达,负责维持高尔基体结构,并通过与Giantin(高尔基体亚家族B成员1)结合,介导高尔基体与内质网(ER)之间的蛋白质运输。ACBD3亚细胞定位的变化会触发高尔基体内的信号级联反应,从而调节细胞命运和细胞周期进程。此外,ACBD3被认为是一种外周型苯二氮卓受体相关蛋白,可能在激素调节和类固醇形成中发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ACBD3 抗体 (518) 参考文献:

  1. 鉴定新型高尔基体蛋白 GCP60 并确定其特性,该蛋白可与整体膜蛋白 giantin 相互作用。  |  Sohda, M., et al. 2001. J Biol Chem. 276: 45298-306. PMID: 11590181
  2. PAP7:一种外周型苯并二氮杂卓受体和 PKA(RIalpha)相关蛋白的鉴定, 定位以及在类固醇生成过程中的功能。  |  Li, H., et al. 2001. Mol Endocrinol. 15: 2211-28. PMID: 11731621
  3. 小鼠 PAP7:一种 PBR 和 PKA-RIalpha 缔合作用蛋白的分子克隆, 基因组组织, 染色体图谱和亚细胞定域。  |  Liu, J., et al. 2003. Gene. 308: 1-10. PMID: 12711385
  4. GCP60 优先与 Caspase 生成的 golgin-160 片段相互作用。  |  Sbodio, JI., et al. 2006. J Biol Chem. 281: 27924-31. PMID: 16870622
  5. NMDA受体-一氧化氮传递通过GTP酶Dexras1介导神经元铁稳态。  |  Cheah, JH., et al. 2006. Neuron. 51: 431-40. PMID: 16908409
  6. 哺乳动物高尔基体通过在有丝分裂过程中释放 ACBD3 来调节不对称细胞分裂中的 numb 信号。  |  Zhou, Y., et al. 2007. Cell. 129: 163-78. PMID: 17418793
  7. 鉴定 GCP60 中调节其与 golgin-160 相互作用的氧化还原敏感半胱氨酸。  |  Sbodio, JI. and Machamer, CE. 2007. J Biol Chem. 282: 29874-81. PMID: 17711851
  8. FAPP2通过维持高尔基体的完整性来转移葡糖基鞘氨醇,需要ACBD3。  |  Liao, J., et al. 2019. J Mol Cell Biol. 11: 107-117. PMID: 29750412
  9. 酰基-CoA结合结构域3(ACBD3;PAP7;GCP60):多功能膜结构域组织者。  |  Yue, X., et al. 2019. Int J Mol Sci. 20: PMID: 31022988
  10. ACBD3 可调节 KDEL 受体与 PKA 的相互作用,使其通过肾小管载体进行转运。  |  Yue, X., et al. 2021. BMC Biol. 19: 194. PMID: 34493279
  11. 乳腺癌细胞中的ACBD3生物信息学分析和蛋白质表达。  |  Houghton-Gisby, J., et al. 2022. Int J Mol Sci. 23: PMID: 36012147
  12. A-激酶锚定蛋白(ACBD3)负责协调高尔基体中由交通诱导的PKA激活。  |  Jia, J., et al. 2023. J Biol Chem. 299: 104696. PMID: 37044218

订购信息

产品名称产品编号规格价格数量收藏夹

ACBD3 抗体 (518)

sc-101277
100 µg/ml
$333.00

ACBD3 (518): m-IgG Fc BP-HRP 套装

sc-539747
100 µg Ab; 10 µg BP
$354.00

ACBD3 (518): m-IgG1 BP-HRP 套装

sc-541682
100 µg Ab; 20 µg BP
$354.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 2
Date published: 2017-02-14
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Rated 3 out of 5 by from Works OKish.Immuno-signal corresponding to published data. Quality depends on applied blocking reagent. Additional unspecific bands occur.
Date published: 2018-04-09
Rated 5 out of 5 by from Great antibody!This antibody is great for WB and IF in both mouse and human cell lines.
Date published: 2017-09-16
Rated 5 out of 5 by from Good product!Used in hepatic cell lysate, obtained a single band at expected size, medium intensity.
Date published: 2017-08-31
Rated 5 out of 5 by from Performs wellThis antibody has great reactivity and performs well in WB and IF assays. It will provide a clear and strong signal and has been used to publish several times.
Date published: 2017-02-07
Rated 5 out of 5 by from WB publishable data with human 293T and HeLaWB publishable data with human 293T and HeLa cells - SCBT Publication Review
Date published: 2015-01-05
Rated 5 out of 5 by from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded human small Intestine tissue. -SCBT QC
Date published: 2013-12-09
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ACBD3 抗体 (518) is rated 4.7 out of 5 by 6.
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