Molecular structure of 8-Isopentenylnaringenin, CAS Number: 68682-02-0
8-Isopentenylnaringenin (CAS 68682-02-0)
Alternate Names:
rac 8-Prenylnaringenin; (±)-8-Prenylnaringenin
Application:
8-Isopentenylnaringenin is a selective, non-steroidal estrogen receptor α (ERα) ligand
CAS Number:
68682-02-0
Molecular Weight:
340.37
Molecular Formula:
C20H20O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-Isopentenylnaringenin is a phytochemical mimicker and/or modulating endogenous estrogens via estrogen receptor binding. Chemopreventive agent against cancer induced by heterocyclic amines. 8-Isopentenylnaringenin is an inhibitor of Mdr-1 and MRP1.
8-Isopentenylnaringenin (CAS 68682-02-0) References
- Stereochemistry of cis- and trans-hinokiresinol and their estrogen-like activity. | Minami, E., et al. 2000. Chem Pharm Bull (Tokyo). 48: 389-92. PMID: 10726863
- Isolation of 10-hydroxycoronaridine from Tabernaemontana penduliflora and its estrogen-like activity. | Masuda, K., et al. 2000. Planta Med. 66: 169-71. PMID: 10763593
- Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin. | Milligan, S., et al. 2002. Reproduction. 123: 235-42. PMID: 11866690
- Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin. | Zierau, O., et al. 2002. Planta Med. 68: 449-51. PMID: 12058324
- Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin. | Zierau, O., et al. 2003. Planta Med. 69: 856-8. PMID: 14598215
- Regulation of gene expression by 8-prenylnaringenin in uterus and liver of Wistar rats. | Diel, P., et al. 2004. Planta Med. 70: 39-44. PMID: 14765291
- Isolation of a new 15-membered macrocyclic glycolipid lactone, Cuscutic Resinoside a from the seeds of Cuscuta chinensis: a stimulator of breast cancer cell proliferation. | Umehara, K., et al. 2004. Planta Med. 70: 299-304. PMID: 15095143
- Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems. | Zierau, O., et al. 2005. Biochem Biophys Res Commun. 326: 909-16. PMID: 15607756
- Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment. | Christoffel, J., et al. 2006. J Endocrinol. 188: 397-405. PMID: 16522720
- Flavonoid-induced autophagy in hormone sensitive breast cancer cells. | Brunelli, E., et al. 2009. Fitoterapia. 80: 327-32. PMID: 19371773
- 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1. | Wesołowska, O., et al. 2010. Eur J Pharmacol. 644: 32-40. PMID: 20633549
- Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats. | Keiler, AM., et al. 2017. J Steroid Biochem Mol Biol. 174: 234-241. PMID: 28964928
- Inhibition of CDCP1 by 8-isopentenylnaringenin synergizes with EGFR inhibitors in lung cancer treatment. | Wong, SC., et al. 2023. Mol Oncol.. PMID: 37013960
- Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship. | Kitaoka, M., et al. 1998. Planta Med. 64: 511-5. PMID: 9741295
- Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism. | Miyamoto, M., et al. 1998. Planta Med. 64: 516-9. PMID: 9741296
Inhibitor of:
Angiogenesis, Mdr-1, and MRP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Isopentenylnaringenin, 5 mg | sc-221146 | 5 mg | $326.00 |