5-trans Latanoprost (free acid) CAS: 903549-49-5
MF: C23H34O5
MW: 390.5
An F-series prostaglandin.

5-trans Latanoprost (free acid) (CAS 903549-49-5)

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应用; 5-trans Latanoprost (free acid) is an F-series prostaglandin
CAS号码: 903549-49-5
分子量: 390.5
分子式: C23H34O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).

5-trans Latanoprost (free acid) is an F-series prostaglandin (PG) analog that was approved for ocular hypotensive drug use. It is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. It is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity in commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, the biological activity of this isomer is likely to be similar to that of the cis isomer. However, there are no specific published reports supporting this. 5-trans Latanoprost (free acid) is an activator of PGF2αR.


1 Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992). 2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

规划 :
A solution in methyl acetate
物理状态 :
溶解度 :
Soluble in water (5 mg/ml at 25.0° C), DMSO, ethanol, DMF, and PBS pH 7.2.
保存 :
Store at -20° C
沸点 :
57° C
折射率 :
n20D 1.56 (Predicted)
PubChem CID :
MDL 号码 :
OC(CCc1ccccc1)CC[[email protected]]1C(O)CC(O)C1C/C=C/CCCC(=O)O




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