Date published: 2025-9-11

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4-oxo 2-Nonenal-d3 (CAS 1313400-91-7)

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应用:
4-oxo 2-Nonenal-d3 是一种 4-ONE 脂质过氧化产物氚化样本
CAS号码:
1313400-91-7
分子量:
157.2
分子式:
C9H11D3O2
补充资料:
此类物品属于危险品,运输时可能需要支付额外运费。
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

快捷链接

4-oxo 2-壬烯醛-d3(4-ONE-d3)在末端甲基位置含有三个氘原子。它是气相色谱或液相色谱-质谱法(MS)量化 4-ONE 的内标。4-ONE 是一种脂质过氧化产物,来源于被氧化的 ω-6 多不饱和脂肪酸,如花生四烯酸和亚油酸(1,2)。 它具有多种生物活性,如细胞毒性、基因毒性、生长抑制活性和趋化活性,并被广泛用作脂质过氧化的标志物(1,2,3)。4-ONE 是最近发现的一种脂质过氧化产物(4,5,6)。它能主动修饰蛋白质上的组氨酸和赖氨酸残基,并导致蛋白质交联(7,8)。4-ONE 还能修饰 2'-deoxy 鸟苷,进一步表明脂质过氧化与诱变和致癌有关(1)。


4-oxo 2-Nonenal-d3 (CAS 1313400-91-7) 参考文献

1 Pryor, W.A., Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990). 2 Esterbauer, H., Schaur, R.J., Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991). 3 Sodum, R.S., Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988). 4 Rindgen, D., Nakajima, M., Wehrli, S., et al. Covalent modifications to 2'-deoxyguanosine by 4-oxo-nonenal, a novel product of lipid peroxidation. Chem Res Toxicol 12 1195-1204 (1999). 5 Lee, S.H., Blair, I.A. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol 13 698-702 (2000). 6 Spiteller, P., Kern, W., Reiner, J., et al. Aldehydic lipid peroxidation products derived from linoleic acid. Biochim Biophys Acta 1531 188-208 (2001). 7 Liu, Z., Minkler, P.E., Sayre, L.M. Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chem Res Toxicol 16 901-911 (2003). 8 Zhang, W., Liu, J., Xu, G., et al. Model studies on protein side chain modification by 4-oxo-2-nonenal. Chem Res Toxicol 16 512-523 (2003).

订购信息

产品名称产品编号规格价格数量收藏夹

4-oxo 2-Nonenal-d3, 50 µg

sc-220992
50 µg
$112.00

4-oxo 2-Nonenal-d3, 100 µg

sc-220992A
100 µg
$214.00