3′,5′-Dimethylacetophenone is an acetophenone compound substituted with two methyl groups on the aryl ring. 3′,5′-Dimethylacetophenone is a potentially useful fragment in synthesis, and may be particularly useful in studies concerning the biological handling of 2′,4′-dihydroxy-3′,5′-dimethylacetophenone (known as clavatol).