2prime,3prime-Dideoxycytidine CAS: 7481-89-2
MF: C9H13N3O3
MW: 211.22
An antiviral pyrimidine nucleoside analogue effective against HIV replication.

2′,3′-Dideoxycytidine (CAS 7481-89-2)

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同义词: ddC
应用; An antiviral pyrimidine nucleoside analogue effective against HIV replication
CAS号码: 7481-89-2
纯度: ≥98%
分子量: 211.22
分子式: C9H13N3O3
* 参考分析证明 大量特定数据 (包括水 含量).
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2′,3′-Dideoxycytidine is an antiviral pyrimidine nucleoside analogue effective against HIV replication. 2′,3′-Dideoxycytidine, when activated to its triphosphate, is incorporated into DNA by HIV-1 RT (HIV-1 reverse transcriptase), causing DNA chain termination and viral replication.


参考文献

1. Broder, S. 1990. Am. J. Med. 88: 2S-7S. PMID: 1692446
2. Anderson, K.S. 2001. Antivir. Chem. Chemother. 12: 13-17. PMID: 11594679
3. Akintonwa, D.A. 2001. Med .Hypotheses. 57: 249-251. PMID: 11461183

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in water (76.4 mg/ml at 25° C), DMSO (42 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
保存 :
Store at -20° C
熔点 :
217-218° C (lit.)
沸点 :
~401.0° C at 760 mmHg (Predicted)
密度 :
~1.6 g/cm3 (Predicted)
折射率 :
n20D 1.69 (Predicted)
光学活性 :
α20/D +90°, c = 0.5 in water; α20/D 77.5°±2.5°, c = 1 in water
IC50 :
CEM: IC50 = 70 nM (human); Vero: IC50 = 94.69 nM (monkey); C8166: IC50 = 125 nM (human); Human immunodeficiency virus 1: IC50 = 130 nM; MT4: IC50 = 1 µM (human)
Ki 数据 :
Human immunodeficiency virus type 1 reverse transcriptase: Ki= 51 nM
pK值 :
pKb: 4.26 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
HA3870000
PubChem CID :
24066
默克索引 :
14: 10109
MDL 号码 :
MFCD00012188
EC号码 :
201-208-6
Beilstein 注册 :
654956
SMILES :
C1C[[email protected]@H](O[[email protected]@H]1CO)N2C=CC(=NC2=O)N

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