2-Hydroxymyristic acid CAS: 2507-55-3
MF: C14H28O3
MW: 244.4
A protein myristoylation inhibitor.

2-Hydroxymyristic acid (CAS 2507-55-3)

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应用; A protein myristoylation inhibitor
CAS号码: 2507-55-3
纯度: >97%
分子量: 244.4
分子式: C14H28O3
* 参考分析证明 大量特定数据 (包括水 含量).
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2-Hydroxymyristic acid has the capability to distinguish between myristoylation and palmitoylation, and is therefore able to inhibit protein myristoylation in cells. Many proteins require myristoylation to be fully active, and inhibition of myristoylation by 2-Hydroxymyristic acid will suppress full protein activity. Metabolic activation to the CoA thioester may be required for inhibitory potency in cells. 2-Hydroxymyristic acid is also capable of reducing the quantity of p56lck, a protein partly responsible for T cell activation, available for signal transduction at the plasma membrane through its inhibition of protein N-myristoylation.


参考文献

1. Paige, L.A., et al. 1990. Biochemistry. 29: 10566-10573. PMID: 2271666
2. Spiegel, A.M., et al. 1991. Trends Biochem. Sci. 16: 338-341. PMID: 1949155
3. Nadler, M.J., et al. 1993. Biochemistry. 32: 9250-9255. PMID: 8103677
4. Paige, L.A., et al. 1993. J. Biol. Chem. 268: 8669-8674. PMID: 8473310
5. Harper, D.R., et al. 1993. J. Gen. Virol. 74: 1181-1184. PMID: 8389801

物理状态 :
Solid
溶解度 :
Soluble in water (0.35 mg/ml), ethanol (≥ 27 mg/ml), DMSO (25 mg/ml), DMF (≥ 27 mg/ml), 100% ethanol (25 mg/ml), chloroform (25 mg/ml), and 1:2 solution of ethanol: PBS(pH 7.2) (~0.35 mg/ml).
保存 :
Store at -20° C
熔点 :
80-81° C
沸点 :
377.45° C at 760 mmHg (Predicted)
密度 :
0.97 g/cm3 (Predicted)
折射率 :
n20D 1.47 (Predicted)
pK值 :
pKa: 3.86 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
1563
MDL 号码 :
MFCD00014342
EC号码 :
219-714-0
Beilstein 注册 :
1725369
SMILES :
CCCCCCCCCCCCC(O)C(O)=O

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PMID: # 26041296  Rathbun, JY. et al. 2015. J. Virol. 89: 8428-43.

PMID: # 19759156  Urata, S. et al. 2009. J. Virol. 83: 12651-12655.

PMID: # 18434404  Life, RB. et al. 2008. J. Virol. 82: 6109-6119.

PMID: # 16617111  Vilas, GL. et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 6542-6547.

PMID: # 15452271  Perez, M. et al. 2004. J. Virol. 78: 11443-11448.

PMID: # 12805216  Saeki, K. et al. 2003. EMBO J. 22: 3015-3026.

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