16,16-dimethyl Prostaglandin A2 CAS: 41691-92-3
MF: C22H34O4
MW: 362.5
A PGA2 analog studied for its antiproliferative properties.

16,16-dimethyl Prostaglandin A2 (CAS 41691-92-3)

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应用; A PGA2 analog studied for its antiproliferative properties
CAS号码: 41691-92-3
分子量: 362.5
分子式: C22H34O4
* 参考分析证明 大量特定数据 (包括水 含量).
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16,16-dimethyl Prostaglandin A2 is a metabolism resistant analog of PGA2 with a relatively prolonged half-life. This compound has been shown to inhibit the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 µg/ml. Additionally, daily infusion of 10 µg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.


参考文献

1. Marini, S., et al., 1990. Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity. British journal of cancer. 61(3): 394-9. PMID: 2328205
2. Santoro, M G., et al., 1988. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus. Archives of virology. 99(1-2): 89-100. PMID: 3355375
3. Santoro, M G., et al., 1980. Prostaglandin A compounds as antiviral agents. Science (New York, N.Y.). 209(4460): 1032-4. PMID: 6157190

规划 :
A solution in methyl acetate
物理状态 :
Liquid
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。

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