Molecular structure of 15-KETE (15-oxo-ETE), CAS Number: 81416-72-0
15-KETE (15-oxo-ETE) (CAS 81416-72-0)
Alternate Names:
15-Ketoeicosa-6E,8Z,11Z,13E-tetraenoic acid; 15-KETE
Application:
15-KETE (15-oxo-ETE) is a major metabolite of arachidonic acid that is formed through the Lipoxygenase pathway
CAS Number:
81416-72-0
Molecular Weight:
318.5
Molecular Formula:
C20H30O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
15-KETE is a major metabolite of arachidonic acid that is formed through the Lipoxygenase pathway in interleukin-4 treated human cord blood derived mast cells. 15-HPETE is enzymatically transformed into 15-KETE from homolytic cleavage of the O-O bond. It has also been found to be a product of the oxidation of 15-HETE by lunch prostaglandin dehydrogenase. In mouse liver, 15-hydroxyeicostatetraenoic acid is found to convert into 15-KETE.
15-KETE (15-oxo-ETE) (CAS 81416-72-0) References
- Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. | Yeh, HC., et al. 2007. Arch Biochem Biophys. 461: 159-68. PMID: 17459323
- Expression of 15-lipoxygenase type-1 in human mast cells. | Gulliksson, M., et al. 2007. Biochim Biophys Acta. 1771: 1156-65. PMID: 17662651
- 15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate. | Sok, DE., et al. 1988. Biochem Biophys Res Commun. 156: 524-9. PMID: 3052453
- Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates. | Cossette, C., et al. 2022. Br J Pharmacol. 179: 322-336. PMID: 34766334
- Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates. | Cossette, C., et al. 2022. Eur J Pharm Sci. 172: 106144. PMID: 35158054
- Multi-Omics Profiling Reveals Resource Allocation and Acclimation Strategies to Temperature Changes in a Marine Dinoflagellate. | Zhang, H., et al. 2022. Appl Environ Microbiol. 88: e0121322. PMID: 35976001
- Oxidation of 15-hydroxyeicosatetraenoic acid and other hydroxy fatty acids by lung prostaglandin dehydrogenase. | Bergholte, JM., et al. 1987. Arch Biochem Biophys. 257: 444-50. PMID: 3662534
- Heat inactive Bacillus subtilis var. natto regulate Nile tilapia (Oreochromis niloticus) intestine microbiota and metabolites involved in the intestine phagosome response. | Pan, PK., et al. 2023. Fish Shellfish Immunol. 134: 108567. PMID: 36731811
- Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist. | Chourey, S., et al. 2023. Chem Pharm Bull (Tokyo). 71: 534-544. PMID: 37394602
- Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024. | Lin, L., et al. 2024. Int Arch Allergy Immunol. 185: 301-310. PMID: 38176394
- 5-Oxo-ETE/OXER1: A Link between Tumor Cells and Macrophages Leading to Regulation of Migration. | Kalyvianaki, K., et al. 2023. Molecules. 29: PMID: 38202807
- A new insight into the key matrix components for aftertaste in Ampelopsis grossedentata (vine tea) infusion: From the intensity and duration of taste profiles using non-targeted metabolomics and molecular simulation. | Chen, L., et al. 2024. Food Chem. 450: 139236. PMID: 38640537
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-KETE (15-oxo-ETE), 50 µg | sc-200977 | 50 µg | $180.00 | |||
15-KETE (15-oxo-ETE), 1 mg | sc-200977A | 1 mg | $1874.00 |