1-Deoxymannojirimycin hydrochloride CAS: 73465-43-7
MF: C6H13NO4•HCl
MW: 199.63
A selective inhibitor of α-mannosidases.

1-Deoxymannojirimycin hydrochloride (CAS 73465-43-7)

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同义词: Deoxymannojirimycin HCl
应用; A selective inhibitor of α-mannosidases
CAS号码: 73465-43-7
纯度: ≥98%
分子量: 199.63
分子式: C6H13NO4•HCl
* 参考分析证明 大量特定数据 (包括水 含量).
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1-Deoxymannojirimycin hydrochloride is a selective inhibitor of α(1→2)-mannosidases. Mannosidases are broken into two subtypes: I and II, which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked α-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked α-D-mannose residues in Man5(GlcNAc)3. Both mannosidase I and mannosidase II of require a divalent cation cofactor.


参考文献

1. Elbein, A.D. 1987. Annu. Rev. Biochem. 56 : 497-534. PMID: 3304143
2. Slusarewicz, P. and Warren, G. 1995. Glycobiology. 5(2): 154-155. PMID: 7780187
3. Lal, A. et al. 1998. Glycobiology. 8(10): 981-995. PMID: 9719679
4. Vallee, F. et al. 2000. J. Biol. Chem. 275(52): 41287-41298. PMID: 10995765
5. van den Elsen, J.M. et al. 2001. EMBO J. 20(12): 3008-3017. PMID: 11406577

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (50 mM), methanol (warm), and DMSO.
保存 :
Store at 4° C
熔点 :
174-176° C
折射率 :
n20D ~1.58 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
11390018
MDL 号码 :
MFCD00083611
SMILES :
C1C(C(C(C(N1)CO)O)O)O.Cl

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PMID: # 26460147  Hiramatsu, R. et al. 2015. Eur. J. Pharmacol. 767: 126-34.

PMID: # 24649404  Mitsuda, S. et al. 2014. FEBS Open Bio. 4: 229-39.

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