Molecular structure of 1-β-D-Arabinofuranosyluracil 5′-Monophosphate, CAS Number: 18354-06-8
1-β-D-Arabinofuranosyluracil 5′-Monophosphate (CAS 18354-06-8)
Alternate Names:
1-(5-O-Phosphono-b-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; Uracil Arabinonucleoside 5′-Phosphate
Application:
1-β-D-Arabinofuranosyluracil 5′-Monophosphate is A metablite of 1-β-D-Arabinofuranosyluracil
CAS Number:
18354-06-8
Molecular Weight:
324.18
Molecular Formula:
C9H13N2O9P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-β-D-arabinofuranosyluracil 5′-monophosphate (Ara5p) is a purine nucleoside that naturally occurs in the fatty acid fraction of erythrocytes. It is prominently expressed in lymphoblasts and leukemia cells. This inhibition is attributed to 1-β-D-arabinofuranosyluracil 5′-monophosphate′s ability to impede the transport of purines across cell membranes, resulting in a reduction in the production of DNA and RNA. Notably, 1-β-D-arabinofuranosyluracil 5′-monophosphate exerts its inhibitory effects by suppressing deaminase activity, which consequently promotes the synthesis of amino acids known for their anti-tumor properties.
1-β-D-Arabinofuranosyluracil 5′-Monophosphate (CAS 18354-06-8) References
- Metabolism and intracellular retention of 1-beta-D-arabinofuranosylcytosine as predictors of response of animal tumors. | Rustum, YM. 1978. Cancer Res. 38: 543-9. PMID: 203383
- Pyrimidine nucleoside monophosphate kinase from human leukemic blast cells. | Hande, KR. and Chabner, BA. 1978. Cancer Res. 38: 579-85. PMID: 203385
- Degradation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human leukemic myeloblasts and lymphoblasts. | Jamieson, GP., et al. 1987. Cancer Res. 47: 3130-5. PMID: 3472653
- Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells. | Müller, WE. and Zahn, RK. 1979. Cancer Res. 39: 1102-7. PMID: 427752
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-β-D-Arabinofuranosyluracil 5′-Monophosphate, 1 mg | sc-208575 | 1 mg | $333.00 |