Gamma-glutamyltransferase (GGT) is an enzyme that plays a crucial role in cellular redox regulation and the metabolism of glutathione, a vital antioxidant molecule. GGT signaling encompasses a network of interactions and pathways involved in maintaining cellular redox balance and managing glutathione levels. This enzyme is primarily localized on the cell membrane and functions to cleave gamma-glutamyl bonds in various substrates, including glutathione. GGT signaling is closely tied to the control of glutathione homeostasis within cells. By catalyzing the breakdown of extracellular glutathione and other gamma-glutamyl compounds, GGT helps regulate the levels of these molecules, which in turn influence redox signaling and antioxidant defense mechanisms.
Gamma-glutamyltransferase (GGT) Activators comprises compounds that have the ability to enhance GGT activity. These activators can interact directly or indirectly with GGT, leading to an increase in its catalytic efficiency. Indirect activators may influence cellular processes that impact GGT expression or activation. The study of GGT activators is essential for unraveling the intricate mechanisms of redox regulation and cellular antioxidant defenses. By understanding how these compounds influence GGT signaling, researchers gain insights into the broader context of cellular redox balance and antioxidant responses, shedding light on fundamental cellular processes that are vital for maintaining health and homeostasis.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
---|---|---|---|---|---|---|
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
谷胱甘肽本身可以作为GGT的激活剂。GGT通过切割细胞外谷胱甘肽中的γ-谷氨酰键来维持细胞内谷胱甘肽水平,这可以间接激活GGT。 | ||||||
Iron | 7439-89-6 | sc-215190 sc-215190A | 500 g 2 kg | $68.00 $176.00 | ||
铁离子,尤其是亚铁(Fe2+)离子,已被证明能激活 GGT。铁能与 GGT 结合并调节其活性,从而有可能提高其催化效率。 | ||||||
S-Nitrosoglutathione (GSNO) | 57564-91-7 | sc-200349 sc-200349B sc-200349A sc-200349C | 10 mg 25 mg 50 mg 100 mg | $85.00 $206.00 $339.00 $449.00 | 15 | |
GSNO 是一种一氧化氮供体,可激活 GGT。它可能会通过影响细胞的氧化还原状态和谷胱甘肽代谢间接刺激 GGT 活性。 | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $50.00 $110.00 $440.00 $1128.00 $2135.00 | 1 | |
L-Cysteine 可以通过提供与酶活性位点相互作用的硫醇基团来激活 GGT。 | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
胰岛素是一种调节葡萄糖代谢的激素。它可以激活 GGT,可能是通过影响细胞的氧化还原状态或调节 GGT 的表达。 |