Date published: 2025-10-14

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Triphenyl phosphate (CAS 115-86-6)

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Alternate Names:
Phosphoric Acid Triphenyl Ester
CAS Number:
115-86-6
Purity:
≥99%
Molecular Weight:
326.28
Molecular Formula:
C18H15O4P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triphenyl phosphate is a chemical compound that functions as a flame retardant and plasticizer in various experimental applications. It acts by forming a protective char layer on the surface of materials, which inhibits the spread of flames and reduces the risk of ignition. At the molecular level, triphenyl phosphate interacts with the polymer matrix, enhancing its resistance to combustion and heat transfer. Triphenyl Phosphate′s mechanism of action involves disrupting the combustion process by releasing phosphoric acid, which promotes the formation of a carbonaceous layer that insulates the material from the heat source. In experimental applications, triphenyl phosphate is utilized to improve the fire safety properties of polymers and other materials without compromising their mechanical or thermal performance. Its role involves investigating its effectiveness in enhancing the flame retardancy of various products and materials.


Triphenyl phosphate (CAS 115-86-6) References

  1. Triphenyl phosphate modulated saturation of phospholipids: Induction of endoplasmic reticulum stress and inflammation.  |  Hu, W., et al. 2020. Environ Pollut. 263: 114474. PMID: 32259740
  2. Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain.  |  Liu, X., et al. 2020. Chemosphere. 252: 126470. PMID: 32443258
  3. Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo.  |  Kim, S., et al. 2020. Arch Toxicol. 94: 3087-3103. PMID: 32683515
  4. Triphenyl phosphate exposure induces kidney structural damage and gut microbiota disorders in mice under different diets.  |  Cui, H., et al. 2020. Environ Int. 144: 106054. PMID: 32818822
  5. Enhanced toxicity of triphenyl phosphate to zebrafish in the presence of micro- and nano-plastics.  |  He, J., et al. 2021. Sci Total Environ. 756: 143986. PMID: 33307501
  6. Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells.  |  Wang, Y., et al. 2021. Chemosphere. 275: 129978. PMID: 33662732
  7. Triphenyl phosphate-induced pericardial edema is associated with elevated epidermal ionocytes within zebrafish embryos.  |  Wiegand, J., et al. 2022. Environ Toxicol Pharmacol. 89: 103776. PMID: 34798236
  8. Ecotoxicity assessment of triphenyl phosphate (TPhP) exposure in Hoplobatrachus rugulosus tadpoles.  |  Chen, JY., et al. 2022. Chemosphere. 292: 133480. PMID: 34974044
  9. Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux.  |  Li, M., et al. 2022. Sci Total Environ. 840: 156461. PMID: 35660595
  10. Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells.  |  Ye, L., et al. 2022. Environ Toxicol. 37: 2445-2459. PMID: 35776891
  11. Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring.  |  Hong, J., et al. 2022. Ecotoxicol Environ Saf. 243: 113978. PMID: 36007322
  12. Triphenyl phosphate activates estrogen receptor α/NF-κB/ cyclin D1 signaling to stimulate cell cycle progression in human Ishikawa endometrial cancer cells.  |  Kwon, HY., et al. 2022. Obstet Gynecol Sci. 65: 531-541. PMID: 36254600
  13. Triphenyl phosphate induced reproductive toxicity through the JNK signaling pathway in Caenorhabditis elegans.  |  Shi, C., et al. 2023. J Hazard Mater. 446: 130643. PMID: 36586333
  14. Triphenyl phosphate-induced pericardial edema in zebrafish embryos is dependent on the ionic strength of exposure media.  |  Wiegand, J., et al. 2023. Environ Int. 172: 107757. PMID: 36680802
  15. Triphenyl phosphate-induced macrophages dysfunction by activation TLR4-mediated ERK/NF-κB pathway.  |  Lin, Z., et al. 2023. Environ Toxicol. 38: 1484-1493. PMID: 36929861

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triphenyl phosphate, 500 g

sc-255701
500 g
$48.00