Molecular structure of Trioxsalen, CAS Number: 3902-71-4
Trioxsalen (CAS 3902-71-4)
Alternate Names:
2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one; 4,5′,8-Trimethylpsoralen; TMP; Trisoralen
Application:
Trioxsalen is a photochemical crosslinker of DNA used as a probe for nucleic acid structure
CAS Number:
3902-71-4
Purity:
≥97%
Molecular Weight:
228.24
Molecular Formula:
C14H12O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trioxsalen is a photochemical crosslinker of DNA that has been used as a probe for nucleic acid structure and function. Trioxsalen has also been used to crosslink DNA onto mica surfaces. Synthesized from para-aminobenzoic acid. Trioxsalen is a 4,5′,8-trimethylated psoralen analog, which belongs to the family of furocoumarins.
Trioxsalen (CAS 3902-71-4) References
- Binding of 4'-aminomethyl 4,5',8-trimethyl psoralen to DNA, RNA and protein in HeLa cells and Drosophila cells. | Frederiksen, S. and Hearst, JE. 1979. Biochim Biophys Acta. 563: 343-55. PMID: 111713
- Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes. | Sánchez Ruderisch, H., et al. 2002. Skin Pharmacol Appl Skin Physiol. 15: 335-41. PMID: 12239428
- Repair of DNA interstrand crosslinks may take place at the nuclear matrix. | Atanassov, B., et al. 2005. J Cell Biochem. 96: 126-36. PMID: 16052506
- DNA interstrand crosslinks repair in mammalian cells. | Mladenova, V. and Russev, G. 2008. Z Naturforsch C J Biosci. 63: 289-96. PMID: 18533476
- Trioxsalen derivatives with lipoxygenase inhibitory activity. | Hadjipavlou-Litina, D., et al. 2009. J Enzyme Inhib Med Chem. 24: 1351-6. PMID: 19912068
- Deciphering the Biomolecules from Bacillus atrophaeus NMB01 Untangles the Anti-Oomycetes Action of Trioxsalen and Corynan-17-ol, Against Phytophthora infestans Inciting Late Blight of Potato. | Ragunathan, J., et al. 2022. Indian J Microbiol. 62: 641-650. PMID: 36458213
- Editorial: Effectiveness of trioxsalen therapy for vitiligo. | Sehgal, VN. 1974. Arch Dermatol. 110: 957-8. PMID: 4441118
- Plasma concentrations after bath treatment and oral administration of trioxsalen. | Fischer, T., et al. 1980. Acta Derm Venereol. 60: 177-79. PMID: 6155034
- Photoaddition of trimethylpsoralen as a probe for the intracellular organization of Escherchia coli DNA. | Hallick, LM., et al. 1980. Nucleic Acids Res. 8: 611-22. PMID: 7003551
- Determination of trioxsalen in human plasma in the picogram range by glass capillary gas chromatography mass spectrometry. | Taskinen, J., et al. 1980. Biomed Mass Spectrom. 7: 556-9. PMID: 7225538
- Long-term local trioxsalen photochemotherapy in psoriasis. | Väätäinen, N., et al. 1981. Dermatologica. 163: 229-31. PMID: 7286362
- Treatment of parapsoriasis en plaques, mycosis fungoides, and Sézary's syndrome with trioxsalen baths followed by ultraviolet light. | Fischer, T. and Skogh, M. 1979. Acta Derm Venereol. 59: 171-3. PMID: 84498
- Bath PUVA--an investigation of the distribution of trioxsalen (TMP) and 8-methoxypsoralen (8-MOP) in bathwater. | Wainwright, NJ., et al. 1997. Photodermatol Photoimmunol Photomed. 13: 17-20. PMID: 9361123
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trioxsalen, 1 g | sc-216017 | 1 g | $71.00 | |||
Trioxsalen, 5 g | sc-216017A | 5 g | $306.00 |