Trioxsalen is a photochemical crosslinker of DNA that has been used as a probe for nucleic acid structure and function. Trioxsalen has also been used to crosslink DNA onto mica surfaces.
Shlyakhtenko, L.S., et al., Atomic force microscopy imaging of DNA covalently immobilized on a functionalized mica substrate. Biophys. J. 77, 568-576, (1999); G.D. Cimino Annu. Rev. Biochem. 54, 1151, (1985); Botta, R., and Gustavino, B., Relationship between chromatin bridges in anaphase and chromosomal aberrations induced by TMP + UVA (365 nm) in CHO cells. Mutat. Res. 374, 253-259, (1997); Mojica, F.J., and Higgins, C.F., Localized domains of DNA supercoiling: topological coupling between promoters. Mol. Microbiol. 22, 919, (1996);
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229-231° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
UN 1759, Class 8, Packing group I
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Nilsen et alNilsen et al. (PubMed ID 25183819) found that trioxsalent, a psoralen derivative, was capable of detecting RNA-RNA interactions in tissue culture cells or in extracts by reducing mobility in polyacrylamide gels. -SCBT Publication Review
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