Date published: 2025-10-11

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Methyl acetoacetate (CAS 105-45-3)

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Alternate Names:
3-Oxobutanoic acid methyl ester; Acetoacetic acid methyl ester; MAA
CAS Number:
105-45-3
Purity:
≥98%
Molecular Weight:
116.12
Molecular Formula:
C5H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl acetoacetate (MAA) is a versatile organic compound. This colorless liquid finds extensive applications in organic synthesis and serves as a valuable reagent in biochemistry. As a ketone ester, Methyl acetoacetate acts as a intermediate in the synthesis of diverse organic compounds. The significance of Methyl acetoacetate in scientific research, particularly in the fields of biochemistry and molecular biology, cannot be understated. In vitro, it serves as a valuable component in the synthesis of small molecules. The function of Methyl acetoacetate as an acetylating agent contributes to the synthesis of proteins, lipids, and other vital biomolecules. Furthermore, it acts as a substrate for the enzyme acetoacetyl-CoA thiolase, catalyzing the cleavage of acetoacetyl-CoA into two molecules of acetyl-CoA. Acetyl-CoA, in turn, becomes a fundamental building block in the synthesis of an array of biomolecules.


Methyl acetoacetate (CAS 105-45-3) References

  1. Chlorine dioxide-iodide-methyl acetoacetate oscillation reaction investigated by UV-vis and online FTIR spectrophotometric method.  |  Shi, L., et al. 2012. ScientificWorldJournal. 2012: 918620. PMID: 22454614
  2. Presolvated electron reactions with methyl acetoacetate: electron localization, proton-deuteron exchange, and H-atom abstraction.  |  Petrovici, A., et al. 2014. Molecules. 19: 13486-97. PMID: 25255751
  3. TiCl4-promoted condensation of methyl acetoacetate, isobutyraldehyde, and indole: a theoretical and experimental study.  |  Renzetti, A., et al. 2015. Phys Chem Chem Phys. 17: 8964-72. PMID: 25746215
  4. RIFM fragrance ingredient safety assessment, methyl acetoacetate, CAS Registry Number 105-45-3.  |  Api, AM., et al. 2019. Food Chem Toxicol. 134 Suppl 1: 110615. PMID: 31238142
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  6. l-Asparagine-EDTA-amide silica-coated MNPs: a highly efficient and nano-ordered multifunctional core-shell organocatalyst for green synthesis of 3,4-dihydropyrimidin-2(1H)-one compounds.  |  Rostami, N., et al. 2022. RSC Adv. 12: 21742-21759. PMID: 36091190
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  8. Carbazole-based photocatalyst (4CzIPN) for novel donor-acceptor (D-A) fluorophore-catalyzed visible-light-induced photosynthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones via a proton-coupled electron transfer (PCET) process.  |  Mohamadpour, F. 2023. RSC Adv. 13: 2514-2522. PMID: 36741179
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl acetoacetate, 100 g

sc-257775
100 g
$20.00

Methyl acetoacetate, 1 kg

sc-257775A
1 kg
$50.00