Molecular structure of Lobeline hydrochloride, CAS Number: 134-63-4
Lobeline hydrochloride (CAS 134-63-4)
Alternate Names:
L-Lobeline hydrochloride; 2-[6-(2-Hydroxy-2-phenethyl)-1-methyl-2-piperidyl]acetophenone hydrochloride
Application:
Lobeline hydrochloride is an AChR agonist
CAS Number:
134-63-4
Purity:
≥97%
Molecular Weight:
373.92
Molecular Formula:
C22H27NO2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lobeline hydrochloride is the hydrochloride salt preparation of Lobeline, a potent agonist of the AChR (nicotinic acetylcholine receptor). Lobeline is demonstrated to increase 86Rb+ efflux at lower concentrations and to reduce 86Rb+ efflux at higher concentrations, suggesting a differential receptor subtype selectivity from nicotine and agonism through a non-nicotinic mechanism. Lobeline is also described to inhibit dopamine uptake into synaptic vesicles.
Lobeline hydrochloride (CAS 134-63-4) References
- Multiple cellular mechanisms mediate the effect of lobeline on the release of norepinephrine. | Sántha, E., et al. 2000. J Pharmacol Exp Ther. 294: 302-7. PMID: 10871326
- Movements of thoracic and abdominal compartments during ventilation at rest and during exercise. | Marlin, DJ., et al. 2002. Equine Vet J Suppl. 384-90. PMID: 12405721
- Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy. | Hozumi, S., et al. 2003. Behav Brain Res. 138: 9-15. PMID: 12493626
- Reflex bronchomotor responses to stimulation of receptors in the regions of the carotid sinus and arch of the aorta in the dog and cat. | DALY, Mde B. and SCHWEITZER, A. 1951. J Physiol. 113: 442-62. PMID: 14851250
- Influence of breathing pattern and lung inflation on impulse oscillometry measurements in horses. | Van Erck, E., et al. 2004. Vet J. 168: 259-69. PMID: 15501143
- Effects of tension of the girth strap on respiratory system mechanics in horses at rest and during hyperpnea induced by administration of lobeline hydrochloride. | Hoffman, AM., et al. 2005. Am J Vet Res. 66: 1167-74. PMID: 16111154
- Acetylcholine neuroprotection against glutamate-induced excitotoxicity in adult pig retinal ganglion cells is partially mediated through alpha4 nAChRs. | Thompson, SA., et al. 2006. Exp Eye Res. 83: 1135-45. PMID: 16928373
- Relations between structure and nicotine-like activity: X-ray crystal structure analysis of (-)-cytisine and (-)-lobeline hydrochloride and a comparison with (-)-nicotine and other nicotine-like compounds. | Barlow, RB. and Johnson, O. 1989. Br J Pharmacol. 98: 799-808. PMID: 2590771
- From cis-Lobeline to trans-Lobeline: Study on the Pharmacodynamics and Isomerization Factors. | Xu, HH., et al. 2022. Molecules. 27: PMID: 36234790
- Pharmacology of lobeline, a nicotinic receptor ligand. | Damaj, MI., et al. 1997. J Pharmacol Exp Ther. 282: 410-9. PMID: 9223582
- Ultrasound spirometry in the horse: a preliminary report on the method and the effects of xylazine and lobeline hydrochloride medication. | Herholz, C., et al. 1997. Schweiz Arch Tierheilkd. 139: 558-63. PMID: 9451919
- Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine. | Teng, L., et al. 1998. J Neurochem. 71: 258-65. PMID: 9648873
- Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine. | Terry, AV., et al. 1998. Neuropharmacology. 37: 93-102. PMID: 9680262
Activator of:
AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lobeline hydrochloride, 50 mg | sc-203114 | 50 mg | $92.00 | |||
Lobeline hydrochloride, 1 g | sc-203114A | 1 g | $209.00 |