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Lidocaine hydrochloride monohydrate (CAS 6108-05-0)

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Alternate Names:
Xylocaine hydrochloride monohydrate
Application:
Lidocaine hydrochloride monohydrate is a fast voltage-gated sodium channel blocker
CAS Number:
6108-05-0
Purity:
≥98%
Molecular Weight:
288.81
Molecular Formula:
C14H22N2O•HCl•H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lidocaine hydrochloride monohydrate is a sodium channel blocker that functions by inhibiting the ionic fluxes required for the initiation and conduction of impulses. It achieves this by altering the permeability of the cell membrane to sodium ions. Lidocaine hydrochloride monohydrate′s mechanism of action involves binding to specific receptors in the sodium channels on the neuronal cell membrane, which prevents the channels from opening and inhibits the conduction of nerve impulses. By doing so, it effectively blocks the sensation of pain by preventing the transmission of signals along nerve fibers. Lidocaine hydrochloride hydrate may stabilize the neuronal membrane and reduce its permeability to sodium ions, thereby decreasing the rate of depolarization and repolarization of the membrane. This ultimately leads to the inhibition of the generation and conduction of nerve impulses, contributing to its functional role in experimental applications.


Lidocaine hydrochloride monohydrate (CAS 6108-05-0) References

  1. On iontophoretic delivery enhancement: ionization and transport properties of lidocaine hydrochloride in aqueous propylene glycol.  |  Karami, K., et al. 2000. Int J Pharm. 201: 121-4. PMID: 10867270
  2. Molecular mechanisms of gating and drug block of sodium channels.  |  Catterall, WA. 2002. Novartis Found Symp. 241: 206-18; discussion 218-32. PMID: 11771647
  3. Local anaesthetic failure in joint hypermobility syndrome.  |  Hakim, AJ., et al. 2005. J R Soc Med. 98: 84-5. PMID: 15684369
  4. Topical lidocaine for the treatment of postherpetic neuralgia.  |  Khaliq, W., et al. 2007. Cochrane Database Syst Rev. CD004846. PMID: 17443559
  5. Effect of lidocaine hydrochloride on the function of bovine peripheral leukocytes.  |  Ando, T., et al. 2009. J Vet Med Sci. 71: 387-90. PMID: 19420838
  6. Tailored beads made of dissolved cellulose--investigation of their drug release properties.  |  Yildir, E., et al. 2013. Int J Pharm. 456: 417-23. PMID: 24012866
  7. Controlled release of local anesthetic from calcium phosphate bone cements.  |  Irbe, Z., et al. 2012. Mater Sci Eng C Mater Biol Appl. 32: 1690-4. PMID: 24364978
  8. The molecular structure and vibrational, (1)H and (13)C NMR spectra of lidocaine hydrochloride monohydrate.  |  Badawi, HM., et al. 2016. Spectrochim Acta A Mol Biomol Spectrosc. 152: 92-100. PMID: 26196935
  9. Controlled release of lidocaine hydrochloride from polymerized drug-based deep-eutectic solvents.  |  Sánchez-Leija, RJ., et al. 2014. J Mater Chem B. 2: 7495-7501. PMID: 32261888
  10. Direct (non-chromatographic) quantification of drugs and their metabolites from human plasma utilizing chemical ionization mass spectrometry and stable isotope labeling: quinidine and lidocaine.  |  Garland, WA., et al. 1974. Biomed Mass Spectrom. 1: 124-9. PMID: 4433724
  11. Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans.  |  Thomson, PD., et al. 1973. Ann Intern Med. 78: 499-508. PMID: 4694036
  12. Fluorometric determination of epinephrine in low dosage injections and in lidocaine hydrochloride-epinephrine combinations.  |  Tames, T. 1973. J Pharm Sci. 62: 669-71. PMID: 4698993
  13. The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.  |  Smith, ER. and Duce, BR. 1971. J Pharmacol Exp Ther. 179: 580-5. PMID: 5138029
  14. Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man.  |  Bennett, PN., et al. 1982. J Pharmacokinet Biopharm. 10: 265-81. PMID: 7175699
  15. Stability-indicating high-performance liquid chromatographic analysis of lidocaine hydrochloride and lidocaine hydrochloride with epinephrine injectable solutions.  |  Waraszkiewicz, SM., et al. 1981. J Pharm Sci. 70: 1215-8. PMID: 7299666

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lidocaine hydrochloride monohydrate, 5 g

sc-202211
5 g
$32.00