Molecular structure of Letrozole, CAS Number: 112809-51-5
Letrozole (CAS 112809-51-5)
See product citations (5)
Alternate Names:
4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Application:
Letrozole is a CYP19 (aromatase) inhibitor
CAS Number:
112809-51-5
Purity:
>98%
Molecular Weight:
285.30
Molecular Formula:
C17H11N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Letrozole acts as a nonsteroidal CYP19 (aromatase) inhibitor. It is also known to inhibit estradiol production in vitro in hamster ovarian tissue that is LH-stimulated. Letrozole has not been shown to have a significant effect on progesterone production up to 350 M. Letrazole has been shown to inhibit aldosterone production in vitro in rat adrenal tissue stimulated by ACTH. No significant effect has been seen on corticosterone production at 350 M. Letrozole has no effect on corticosterone or aldoterone levels in vivo in ACTH-treated rats.
Letrozole (CAS 112809-51-5) References
Ingle JN. Oncology (Huntingt). 15:28-34 (2001). Bhatnagar AS, Hausler A, Schieweck K et al. J Steroid Biochem Mol Biol. 37:1021-7 (1990). Brodie AM. J Steroid Biochem Mol Biol. 49:281-7 (1994).Inhibitor of:
11β-HSD2, 17-β Estradiol, 17-β Estradiol 6, 17β-HSD, 17β-HSD11, 17β-HSD14, 17β-HSD2, 17β-HSD3, 17β-HSD6, 17β-HSD7, 3β-HSD3, 3β-HSD4, 3β-HSD5, 4921511H03Rik, 4933421E11Rik, Abp ε, AKR1D1, BOULE, Choriogonadotropin, Choriogonadotropin Holo c2, Choriogonadotropin Holo c3, CSH1, CYP19, Cyp3a41b, EEIG1, EG639025, EG667693, EHZF, ER, ER alpha, Estradiol, Estriol, EXD, Fdx1, FOXL2, FSH, FSHα, GCDFP-15, Gm694, GnRH-associated peptide, Gonadotropin α, Gonadotropin β, GREB1, Gros1, INSL3, LOC100039517, LRP16, MEA-1, mPRε, MUP11, NOBOX, Olr507, Olr690, Olr727, Ott, Oviductin, Plfr, Prl2c1, Purγ, Rhox2, Rhox4, SAF-B2, SHBG, Sp2, Spatial, SPEER-2, StARD5, SYCE1L, TEX30, TSARG6, V1RI9, Vmn2r23, Zinc-finger protein (ZNF), ZNF703, ZP1, ZP2, and ZP3.Activator of:
17β-HSD, 17β-HSD14, BPY2, Choriogonadotropin, Choriogonadotropin β, Estradiol, FSH, Gonadotropin β, hCG_38480, Inhibin β-A, Kap, KiSS-1, MIS, NOBOX, PELP1, Placental lactogen I, SSX3, TOPAZ1, and TSARG2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Letrozole, 25 mg | sc-204791 | 25 mg | $85.00 | |||
Letrozole, 50 mg | sc-204791A | 50 mg | $144.00 |