Date published: 2025-9-16

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Kojic acid (CAS 501-30-4)

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Alternate Names:
5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; 5-Hydroxy-2-(hydroxymethyl)-4-pyrone; 5-Hydroxy-2-hydroxymethyl-4-pyrone
Application:
Kojic acid is a tyrosine kinase inhibitor that acts as a chelation agent which inhibits melanin production.
CAS Number:
501-30-4
Purity:
≥99%
Molecular Weight:
142.11
Molecular Formula:
C6H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Kojic acid is a compound found in various species of fungi and is notable for its ability to chelate metal ions, which has made it a subject of interest in multiple research fields. In the area of biochemistry, kojic acid is studied for its role as an inhibitor of certain enzymes, such as tyrosinase, which is involved in the biosynthesis of melanin. This property forms the basis for research into the mechanisms of pigment formation and pigmentation disorders. In the field of agriculture, kojic acid is examined for its potential as a natural plant growth regulator and as a compound that can influence the pathogenicity of certain plant pests. Additionally, kojic acid is used as a reagent in organic synthesis, where its ability to form stable complexes with transition metals is exploited in the development of new catalytic systems. Research into the antimicrobial properties of kojic acid is also conducted, focusing on its effects against a range of microorganisms and its potential application in food preservation.


Kojic acid (CAS 501-30-4) References

  1. Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid.  |  Rodrigues, JC., et al. 2022. Int J Microbiol. 2022: 4010018. PMID: 35620355
  2. Biological activities and safety data of kojic acid and its derivatives: A review.  |  Zilles, JC., et al. 2022. Exp Dermatol. 31: 1500-1521. PMID: 35960194
  3. A Novel Major Facilitator Superfamily Transporter Gene Aokap4 near the Kojic Acid Gene Cluster Is Involved in Growth and Kojic Acid Production in Aspergillus oryzae.  |  Chen, T., et al. 2022. J Fungi (Basel). 8: PMID: 36012873
  4. Facile and sensitive photoelectrochemical detection of kojic acid in food products: a general strategy for immobilization-free analysis of enzyme inhibitors.  |  Zhang, N., et al. 2022. Analyst. 147: 5579-5585. PMID: 36349930
  5. Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety.  |  Peng, Z., et al. 2023. Curr Res Food Sci. 6: 100421. PMID: 36605465
  6. Effects of kojic acid on changes in the microstructure and myofibrillar protein of duck meat during superchilled storage.  |  Hou, W., et al. 2023. J Food Sci. 88: 977-987. PMID: 36650660
  7. Detoxication of Citrinin with Kojic Acid by the Formation of the Citrinin-Kojic Acid Adduct, and the Enhancement of Kojic Acid Production by Citrinin via Oxidative Stress in Aspergillus parasiticus.  |  Ichinomiya, M., et al. 2022. J Fungi (Basel). 9: PMID: 36675872
  8. Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications.  |  Sun, R., et al. 2023. Molecules. 28: PMID: 36770910
  9. Kojic Acid Gene Clusters and the Transcriptional Activation Mechanism of Aspergillus flavus KojR on Expression of Clustered Genes.  |  Chang, PK., et al. 2023. J Fungi (Basel). 9: PMID: 36836373
  10. Effective production of kojic acid in engineered Aspergillus niger.  |  Wu, L., et al. 2023. Microb Cell Fact. 22: 40. PMID: 36843006
  11. Searching for Suitable Kojic Acid Coformers: From Cocrystals and Salt to Eutectics.  |  Sun, R., et al. 2023. Cryst Growth Des. 23: 1874-1887. PMID: 36879772
  12. Fungal production of kojic acid and its industrial applications.  |  Chib, S., et al. 2023. Appl Microbiol Biotechnol. 107: 2111-2130. PMID: 36912905
  13. Kojic Acid and Kojic Acid Ester: Review on Nanotechnology-based Approach for Enhancing the Delivery Efficacy.  |  Lokman Hakim, NYD., et al. 2023. Recent Adv Drug Deliv Formul.. PMID: 37038680
  14. Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging-Preliminary Study.  |  Wawrzyk-Bochenek, I., et al. 2023. J Clin Med. 12: PMID: 37048793

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Kojic acid, 5 g

sc-255228
5 g
$92.00

Kojic acid, 25 g

sc-255228A
25 g
$173.00