Molecular structure of Guanidinoacetic Acid, CAS Number: 352-97-6
Guanidinoacetic Acid (CAS 352-97-6)
Alternate Names:
N-(Aminoiminomethyl)-glycine
Application:
Guanidinoacetic Acid is used as a substrate for the assay of glycocyamine kinase
CAS Number:
352-97-6
Purity:
99%
Molecular Weight:
117.11
Molecular Formula:
C3H7N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanidinoacetic acid is a precursor to creatine, a compound involved in energy metabolism. Within the experimental, it functions as a substrate for the enzyme guanidinoacetate methyltransferase, which catalyzes the methylation of guanidinoacetic acid to form creatine. This process occurs in the liver and kidneys, where guanidinoacetic acid is converted to creatine through a series of enzymatic reactions. The mechanism of action involves the transfer of a methyl group from S-adenosylmethionine to guanidinoacetic acid, resulting in the formation of creatine. This conversion is used for maintaining adequate levels of creatine in tissues with high and fluctuating energy demands, such as muscle and brain tissue. Guanidinoacetic acid plays a role in the biosynthesis of creatine, which is important for cellular energy homeostasis.
Guanidinoacetic Acid (CAS 352-97-6) References
- Age-Related Changes in Serum Guanidinoacetic Acid in Women. | Olah, A., et al. 2019. Physiol Res. 68: 1033-1036. PMID: 31647299
- Guanidinoacetic acid supplementation is favourable to broiler diets even containing poultry by-product meal. | Çenesiz, AA., et al. 2020. Br Poult Sci. 61: 311-319. PMID: 32019332
- Human gut microbiota as a source of guanidinoacetic acid. | Ostojic, SM. 2020. Med Hypotheses. 142: 109745. PMID: 32344286
- Dietary guanidinoacetic acid supplementation improved carcass characteristics, meat quality and muscle fibre traits in growing-finishing gilts. | Zhu, Z., et al. 2020. J Anim Physiol Anim Nutr (Berl). 104: 1454-1461. PMID: 32618065
- Relative bioavailability of guanidinoacetic acid delivered ruminally or abomasally to cattle. | Speer, HF., et al. 2020. J Anim Sci. 98: PMID: 32845973
- Guanidinoacetic acid supplementation improves feed conversion in broilers subjected to heat stress associated with muscle creatine loading and arginine sparing. | Majdeddin, M., et al. 2020. Poult Sci. 99: 4442-4453. PMID: 32867988
- Effects of guanidinoacetic acid and coated folic acid supplementation on growth performance, nutrient digestion and hepatic gene expression in Angus bulls. | Liu, YJ., et al. 2021. Br J Nutr. 126: 510-517. PMID: 33143765
- Effects of guanidinoacetic acid supplementation on nitrogen retention and methionine flux in cattle. | Ardalan, M., et al. 2021. J Anim Sci. 99: PMID: 34165572
- Feeding guanidinoacetic acid to broiler chickens can compensate for low dietary metabolisable energy formulation. | Pirgozliev, V., et al. 2022. Br Poult Sci. 63: 368-374. PMID: 34874208
- Guanidinoacetic acid as a partial replacement to arginine with or without betaine in broilers offered moderately low crude protein diets. | Sharma, NK., et al. 2022. Poult Sci. 101: 101692. PMID: 35124444
- Effects of dietary guanidinoacetic acid on growth performance, guanidinoacetic acid absorption and creatine metabolism of lambs. | Zhang, S., et al. 2022. PLoS One. 17: e0264864. PMID: 35275964
- Cataloguing guanidinoacetic acid content in various foods. | Ostojic, SM. 2022. Int J Vitam Nutr Res. 92: 158-160. PMID: 35291874
- Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats. | Prokic, VZ., et al. 2022. Can J Physiol Pharmacol. 100: 772-786. PMID: 35894232
- Cataloguing guanidinoacetic acid content in nutritional supplements. | Ostojic, SM., et al. 2023. Food Sci Nutr. 11: 1603-1605. PMID: 37051371
Inhibitor of:
ASS1, GAMT, Gatm, P5CRL, PEMT, and SLC6A8.Activator of:
CKMT1B, and GlyT2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanidinoacetic Acid, 25 mg | sc-211571 | 25 mg | $166.00 | |||
Guanidinoacetic Acid, 1 g | sc-211571A | 1 g | $217.00 | |||
Guanidinoacetic Acid, 5 g | sc-211571B | 5 g | $273.00 |