Gingerol (CAS 23513-14-6)
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Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, may act to stimulate the Ca2+-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca2+-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it may act to have apoptotic properties.
Gingerol (CAS 23513-14-6) References
- Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol. | Lee, E. and Surh, YJ. 1998. Cancer Lett. 134: 163-8. PMID: 10025876
- Gingerols: a novel class of vanilloid receptor (VR1) agonists. | Dedov, VN., et al. 2002. Br J Pharmacol. 137: 793-8. PMID: 12411409
- Gingerol-induced hypoxia-inducible factor 1 alpha inhibits human prion peptide-mediated neurotoxicity. | Jeong, JK., et al. 2013. Phytother Res. 27: 1185-92. PMID: 23008012
- Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum. | Kobayashi, M., et al. 1987. Biochim Biophys Acta. 903: 96-102. PMID: 2443170
- The influence of gingerol treatment on aluminum toxicity in rats. | Shrivastava, S. 2015. J Environ Pathol Toxicol Oncol. 34: 11-21. PMID: 25746828
- Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation. | Jain, M., et al. 2016. J Cardiovasc Pharmacol Ther. 21: 187-200. PMID: 26240073
- Gingerol Reverses the Cancer-Promoting Effect of Capsaicin by Increased TRPV1 Level in a Urethane-Induced Lung Carcinogenic Model. | Geng, S., et al. 2016. J Agric Food Chem. 64: 6203-11. PMID: 27436516
- Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract. | Yang, MQ., et al. 2016. Chin J Nat Med. 14: 434-40. PMID: 27473961
- Anti-Inflammatory Effects of Gingerol on Lipopolysaccharide-Stimulated RAW 264.7 Cells by Inhibiting NF-κB Signaling Pathway. | Liang, N., et al. 2018. Inflammation. 41: 835-845. PMID: 29508185
- The rise of gingerol as anti-QS molecule: Darkest episode in the LuxR-mediated bioluminescence saga. | Parmar, P., et al. 2020. Bioorg Chem. 99: 103823. PMID: 32283347
- Breaking bad: Better call gingerol for improving antibiotic susceptibility of Pseudomonas aeruginosa by inhibiting multiple quorum sensing pathways. | Shukla, A., et al. 2021. Microbiol Res. 252: 126863. PMID: 34530246
- Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. | Zhai, Y., et al. 2022. Kaohsiung J Med Sci. 38: 367-377. PMID: 34962339
- Gingerol fractions bioactivity against butanone cytotoxicity induced in newborns of mice. | Othman, SI., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 6512-6522. PMID: 36196700
- Integrated chromatographic approach for the discovery of gingerol antioxidants from Dracocephalum heterophyllum and their potential targets. | Dang, J., et al. 2022. Anal Methods. 14: 4133-4145. PMID: 36226573
- Antiplatelet effect of gingerol isolated from Zingiber officinale. | Guh, JH., et al. 1995. J Pharm Pharmacol. 47: 329-32. PMID: 7791032
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gingerol, 5 mg | sc-201519 | 5 mg | $109.00 | |||
Gingerol, 20 mg | sc-201519A | 20 mg | $387.00 |