Gabaculine A conformationally constrained analog of GABA

Gabaculine (CAS 59556-17-1)

Gabaculine | CAS 59556-17-1 is rated 5.0 out of 5 by 1.
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| See product citations (2)
Synonym: (±)-Amino-2,3-dihydrobenzoic acid hydrochloride
Application: A conformationally constrained analog of GABA
CAS Number: 59556-17-1
Purity: ≥95%
Molecular Weight: 175.61
Molecular Formula: C7H9NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Gabaculine sc-200473 10 mg $300.00
Gabaculine sc-200473A 50 mg $638.00

Gabaculine is a conformationally constrained analog of γ-aminobutyric acid (GABA). It acts as an irreversible and potent inhibitor of GABA transaminase, the enzyme that converts GABA in the brain into succinate semialdehyde that can enter the citric acid Gabaculine is a substrate of GABA Receptor.


References

1. Rando, R.R. 1977. Biochemistry. 16: 4604-4610. PMID: 410442
2. Metcalf, B.W. 1979. Biochem. Pharmacol. 28: 1705-1712. PMID: 383082
3. Löscher, W. 1980. Naunyn Schmiedebergs Arch. Pharmacol. 315: 119-128. PMID: 6782493

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
203-206° C (dec.)
Refractive Index :
n20D 1.57 (Predicted)
pK Values :
pKa: 3.75 (Predicted), pKb: 8.86 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GU4775000
PubChem CID :
198382
MDL Number :
MFCD00036983
EC Number :
261-802-6
Beilstein Registry :
4552667
SMILES :
C1C(C=CC=C1C(=O)O)N.Cl

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Certificate of Analysis

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Citations 1 to 2 of 2 total

PMID: # 17320182  Crooks, DR et al. 2007. Neurotoxicology. 3: 548-54.

PMID: # 9405452  Kuras, R. et al. 1997. J. Biol. Chem. 272: 32427-32435.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Crooks Crooks, et. al. (PubMed ID 17320182) utilized gabaculine, a GABA-T inhibitor, in a control reaction to confirm specificity of the GABA-T enzyme assay performed. -SCBT Publication Review
Date published: 2015-04-07
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