Date published: 2025-10-3

1-800-457-3801

SCBT Portrait Logo
Seach Input

Flumequine (CAS 42835-25-6)

0.0(0)
Write a reviewAsk a question

CAS Number:
42835-25-6
Molecular Weight:
261.25
Molecular Formula:
C14H12FNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Flumequine interacts with cellular components by inhibiting the activity of bacterial DNA gyrase, an enzyme involved in DNA replication and repair. This leads to the disruption of bacterial DNA synthesis and ultimately results in cell death. Flumequine targets the A subunit of DNA gyrase, preventing the enzyme from introducing negative supercoils into the bacterial DNA. As a result, the normal cellular processes of the bacteria are disrupted, leading to their inability to proliferate and causing their eventual demise. This mechanism of action makes flumequine an effective antimicrobial agent against a wide range of gram-negative and gram-positive bacteria. By targeting the DNA gyrase enzyme, flumequine exerts its influence on cellular processes, ultimately leading to the inhibition of bacterial growth and the resolution of bacterial infections.


Flumequine (CAS 42835-25-6) References

  1. Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.  |  Kuroda, K., et al. 2013. Arch Toxicol. 87: 1609-19. PMID: 23681119
  2. Toxicological Evaluation of Flumequine in Pubertal Male Rats After Oral Administration for Six Weeks.  |  Kang, J., et al. 2018. J Vet Res. 62: 87-96. PMID: 29978132
  3. Transgenerational toxicity of flumequine over four generations of Daphnia magna.  |  De Liguoro, M., et al. 2019. Ecotoxicol Environ Saf. 169: 814-821. PMID: 30597780
  4. Flumequine-Mediated Upregulation of p38 MAPK and JNK Results in Melanogenesis in B16F10 Cells and Zebrafish Larvae.  |  Karunarathne, WAHM., et al. 2019. Biomolecules. 9: PMID: 31614510
  5. Pharmacokinetic Data Show That Oxolinic Acid and Flumequine Are Absorbed and Excreted Rapidly From Plasma and Tissues of Lumpfish.  |  Haugland, GT., et al. 2019. Front Vet Sci. 6: 394. PMID: 31781582
  6. Characterization of Mechanisms Lowering Susceptibility to Flumequine among Bacteria Isolated from Chilean Salmonid Farms.  |  Concha, C., et al. 2019. Microorganisms. 7: PMID: 31847389
  7. Flumequine (Veterinary Medicinal Products).  |  ,. 2020. Food Saf (Tokyo). 8: 8-9. PMID: 32231958
  8. Nano-immobilized flumequine with preserved antibacterial efficacy.  |  Bortoletti, M., et al. 2020. Colloids Surf B Biointerfaces. 191: 111019. PMID: 32305623
  9. Antibiotics florfenicol and flumequine in the water column and sediments of Puyuhuapi Fjord, Chilean Patagonia.  |  Jara, B., et al. 2021. Chemosphere. 275: 130029. PMID: 33984897
  10. Distribution of Flumequine in Intestinal Contents and Colon Tissue in Pigs after Its Therapeutic Use in the Drinking Water.  |  Rodríguez, JM., et al. 2021. Animals (Basel). 11: PMID: 34071041
  11. Clinical pharmacokinetics of flumequine in calves.  |  Ziv, G., et al. 1986. J Vet Pharmacol Ther. 9: 171-82. PMID: 3522937
  12. Water-sediment partitioning of flumequine and florfenicol, two antibiotics used in salmon aquaculture in Chile.  |  Jara, B., et al. 2022. Mar Pollut Bull. 177: 113480. PMID: 35305371
  13. Flumequine-loaded titanate nanotubes as antibacterial agents for aquaculture farms.  |  Baati, T., et al. 2022. RSC Adv. 12: 5953-5963. PMID: 35424545
  14. Kinetics and mechanisms of flumequine degradation by sulfate radical based AOP in different water samples containing inorganic anions.  |  Zhang, Y., et al. 2022. RSC Adv. 12: 10088-10096. PMID: 35424923

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Flumequine, 1 g

sc-211519
1 g
$95.00