Dextromethorphan Hydrobromide A potentially useful NMDA receptor agonist

Dextromethorphan Hydrobromide (CAS 125-69-9)

Dextromethorphan Hydrobromide | CAS 125-69-9 is rated 5.0 out of 5 by 1.
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Synonym: (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
Application: A potentially useful NMDA receptor agonist
CAS Number: 125-69-9
Purity: ≥98%
Molecular Weight: 352.31
Molecular Formula: C18H25NO•HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dextromethorphan Hydrobromide is a low affinity NMDA receptor antagonist. It is the d-form of racemethorphan.


References

1. Choi, D.W. et al. 1987. J. Pharmacol. Exp. Ther. 242(2): 713-720. PMID: 3039122

2. Tortella, F.C. et al. 1989. Trends Pharmacol. Sci. 10(12): 501-507. PMID: 2694543

Physical State :
Solid
Solubility :
Soluble in water (40 mM), and alcohol (1:10).
Storage :
Store at room temperature
Melting Point :
125° C (lit.)(dec.)
Boiling Point :
427.5° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D +26.6°, c = 1.08 in 0.1N Hydrochloric Acid
IC50 :
ST: IC50 = 2.71 nM (human); σ-1 receptor: IC50 = 15.2 nM (guinea pig); Plasmodium falciparum: IC50 = 794.33 nM; Sodium channel α subunits; brain (Types I, II, III): IC50 = 1.3 µM (rat); CYP2D6: IC50 = 1.8 µM (human)
Ki Data :
ST: Ki= 1.44 nM (human); Sigma Receptor: Ki= 348 nM (human); NMDA receptor: Ki= 1.68 µM (human); NMDA receptor: Ki= 2.25 µM (rat); σ opioid receptor: Ki= 5.07 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QD0222000
PubChem CID :
5702039
Merck Index :
14: 8091
MDL Number :
MFCD00269810
EC Number :
204-750-1
Beilstein Registry :
6453793
SMILES :
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.Br

Download SDS (MSDS)

Certificate of Analysis

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What is the boiling point of this compound

Asked by: suhail
Thank you for your question. This product, sc-204716 (Dextromethorphan Hydrobromide) is a solid. Here is a link to the CoA for our latest lot: http://datasheets.scbt.com/coa/coa.php?sc=sc-204716&lot=L1416 If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-09-25
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Rated 5 out of 5 by from Wu Wu, K. et al. (PubMed 23400250) reported that the NMDA receptor agonist Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced NF- B activation. -SCBT Publication Review
Date published: 2015-02-14
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