Date published: 2025-9-18

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D-Glucosamine (CAS 3416-24-8)

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CAS Number:
3416-24-8
Molecular Weight:
179.17
Molecular Formula:
C6H13NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Glucosamine is an amino sugar found in the fluid around the joints and in connective tissue. It plays a role in the synthesis and maintenance of cartilage. It is a key building block for glycosaminoglycans (GAGs) and proteoglycans, which are essential components of cartilage structure. D-Glucosamine is believed to stimulate the production of new cartilage. D-Glucosamine is used as a substrate in enzymatic assays and metabolic studies to investigate various biochemical pathways.


D-Glucosamine (CAS 3416-24-8) References

  1. D-glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K.  |  Oh, HJ., et al. 2007. Biochem Biophys Res Commun. 360: 840-5. PMID: 17624310
  2. D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells.  |  Park, JY., et al. 2009. Biochem Biophys Res Commun. 382: 96-101. PMID: 19254699
  3. D-glucosamine promotes transfection efficiency during electroporation.  |  Igawa, K., et al. 2014. Biomed Res Int. 2014: 485867. PMID: 24678506
  4. The shape of D-glucosamine.  |  Peña, I., et al. 2014. Phys Chem Chem Phys. 16: 23244-50. PMID: 25255812
  5. 1H NMR studies of molecular interaction of D-glucosamine and N-acetyl-D-glucosamine with capsaicin in aqueous and non-aqueous media.  |  Higuera-Ciapara, I., et al. 2017. Carbohydr Res. 452: 6-16. PMID: 28992455
  6. Formulation of anomerization and protonation in d-glucosamine, based on 1H NMR.  |  Virués, C., et al. 2020. Carbohydr Res. 490: 107952. PMID: 32114014
  7. Comparison of acidity and metal ion affinity of D-Glucosamine and N-acetyl-D-glucosamine, a DFT study.  |  Kotena, ZM. and Fattahi, A. 2020. J Mol Graph Model. 98: 107612. PMID: 32302939
  8. Enhancement of Production of D-Glucosamine in Escherichia coli by Blocking Three Pathways Involved in the Consumption of GlcN and GlcNAc.  |  Li, P., et al. 2020. Mol Biotechnol. 62: 387-399. PMID: 32572810
  9. The study of the acid-catalyzed reaction between 2-methyl and 2-(2,2,2-trichloroethoxy) gluco-[2,1-d]-2-oxazolines. Synthesis of macrocyclic pseudo-tetrasaccharide derivative of d-glucosamine.  |  Pertel, SS., et al. 2021. Carbohydr Res. 499: 108230. PMID: 33429169
  10. Amino Acid Ionic Liquids Catalyzed d-Glucosamine into Pyrazine Derivatives: Insight from NMR Spectroscopy.  |  Liu, P., et al. 2021. J Agric Food Chem. 69: 2403-2411. PMID: 33595305
  11. d-Glucosamine as the Green Ligand for Cu(I)-Catalyzed Regio- and Stereoselective Domino Synthesis of (Z)-3-Methyleneisoindoline-1-ones and (E)-N-Aryl-4H-thiochromen-4-imines.  |  Singh, SK., et al. 2021. ACS Omega. 6: 21125-21138. PMID: 34423220
  12. Anomeric Stereoauxiliary Cleavage of the C-N Bond of d-Glucosamine for the Preparation of Imidazo[1,5-a]pyridines.  |  Zeng, K., et al. 2022. Chemistry. 28: e202200648. PMID: 35319128
  13. Preparation of the porous carbon-based solid acid from starch for efficient degradation of chitosan to D-glucosamine.  |  Wang, W., et al. 2022. Int J Biol Macromol. 209: 1629-1637. PMID: 35447270
  14. d-Glucosamine production from chitosan hydrolyzation over a glucose-derived solid acid catalyst.  |  Zhang, H., et al. 2018. RSC Adv. 8: 5608-5613. PMID: 35542433
  15. Corrigendum: Anomeric Stereoauxiliary Cleavage of the C-N Bond of d-Glucosamine for the Preparation of Imidazo[1,5-a]pyridines.  |  Zeng, K., et al. 2022. Chemistry. 28: e202202181. PMID: 35852152

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Glucosamine, 1 g

sc-278917A
1 g
$197.00

D-Glucosamine, 10 g

sc-278917
10 g
$764.00