Date published: 2025-10-14

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D-Cysteine (CAS 921-01-7)

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Alternate Names:
(S)-2-Amino-3-mercaptopropionic acid
Application:
D-Cysteine is an unnatural isomer of cysteine
CAS Number:
921-01-7
Purity:
≥98%
Molecular Weight:
121.16
Molecular Formula:
C3H7NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Cysteine is a non-proteinogenic amino acid that serves as a research tool in various biochemical and physiological studies. In research, D-Cysteine is used to investigate the metabolic pathways and mechanisms of amino acid metabolism, particularly the role of D-amino acids in organisms. It is also employed in studies of enzymatic activity, where researchers explore the substrate specificity of certain enzymes, such as D-amino acid oxidase, which is involved in the catabolism of D-amino acids. Moreover, D-Cysteine is utilized in studies focused on the generation of hydrogen sulfide (H2S) in biological systems, as it can serve as a precursor to H2S through enzymatic and non-enzymatic pathways. This has implications for understanding the signaling functions of hydrogen sulfide in various physiological processes. Additionally, the compound is used in research on redox biology, owing to its potential to influence thiol-disulfide exchange reactions within cells.


D-Cysteine (CAS 921-01-7) References

  1. Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine.  |  Soutourina, J., et al. 2001. J Biol Chem. 276: 40864-72. PMID: 11527960
  2. D-Cysteine desulfhydrase in Escherichia coli.  |  SAZ, A. and BROWNELL, LW. 1954. Arch Biochem Biophys. 52: 291-3. PMID: 13198265
  3. Evidence that d-cysteine protects mice from gastric damage via hydrogen sulfide produced by d-amino acid oxidase.  |  Souza, LK., et al. 2017. Nitric Oxide. 64: 1-6. PMID: 28137610
  4. d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils.  |  Ruckthong, L., et al. 2017. Chemistry. 23: 8232-8243. PMID: 28384393
  5. Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration.  |  Shibui, Y., et al. 2017. J Toxicol Pathol. 30: 217-229. PMID: 28798529
  6. d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production.  |  Seki, T., et al. 2018. Mol Cell Neurosci. 93: 36-47. PMID: 30342995
  7. 18F-Trifluoromethylated D-Cysteine as a Promising New PET Tracer for Glioma Imaging: Comparative Analysis With MRI and Histopathology in Orthotopic C6 Models.  |  Ma, H., et al. 2021. Front Oncol. 11: 645162. PMID: 33996562
  8. Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia.  |  Ohta, T., et al. 2021. Exp Neurol. 343: 113791. PMID: 34157318
  9. Investigation of microbiologically influenced corrosion inhibition of 304 stainless steel by D-cysteine in the presence of Pseudomonas aeruginosa.  |  Qian, HC., et al. 2022. Bioelectrochemistry. 143: 107953. PMID: 34583211
  10. Separation and determination of cysteine enantiomers in plasma after derivatization with 4-fluoro-7-nitrobenzofurazan.  |  Ferré, S., et al. 2022. J Pharm Biomed Anal. 209: 114539. PMID: 34954468
  11. D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation.  |  Ueda, E., et al. 2022. Cells. 11: PMID: 35406792
  12. D-cysteine ethyl ester and D-cystine dimethyl ester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats.  |  Getsy, PM., et al. 2022. Respir Physiol Neurobiol. 302: 103912. PMID: 35447347
  13. D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood-Gas Chemistry in Freely-Moving Rats.  |  Getsy, PM., et al. 2022. Front Pharmacol. 13: 883329. PMID: 35814208
  14. Comparative and Selective Interaction of Amino Acid d-Cysteine with Colloidal Gold Nanoparticles in the Presence of a Fluorescent Probe in Aqueous Medium.  |  Maiti, P., et al. 2022. ACS Omega. 7: 29013-29026. PMID: 36033694
  15. The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the rat.  |  Krijgsheld, KR., et al. 1981. Biochim Biophys Acta. 677: 7-12. PMID: 7295791

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Cysteine, 1 g

sc-255054
1 g
$70.00

D-Cysteine, 5 g

sc-255054A
5 g
$100.00

D-Cysteine, 25 g

sc-255054B
25 g
$200.00

D-Cysteine, 100 g

sc-255054C
100 g
$520.00

D-Cysteine, 250 g

sc-255054D
250 g
$1105.00