Cytochalasin A (CAS 14110-64-6)
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Cytochalasin A is used in actin polymerization studies. It is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. It can be employed as a tool for cytological research. The class of Cytochalasin fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin A is the oxidized analog of cytochalastin B (sc-3519). As opposed to other Cytochalasins, Cytochalasin A and cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin A is sulfhydryl-reactive, and was shown to inhibit growth and sugar uptake in a Saccharomyces strain. It also inhibits HIV-1 protease (sc-51614). Other Cytochalasins available: Cytochalasin C (sc-202118) Cytochalasin D (sc-201442) Cytochalasin E, Aspergillus clavatus (sc-202561) Cytochalasin H (sc-202119) Cytochalasin J (sc-202120)
Cytochalasin A (CAS 14110-64-6) References
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- Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. | Yahara, I., et al. 1982. J Cell Biol. 92: 69-78. PMID: 7199054
- Inhibition of histamine release from rat mast cells by cytochalasin A and other sulfhydryl reagents. | Lagunoff, D. and Wan, H. 1979. Biochem Pharmacol. 28: 1765-9. PMID: 89848
- Effect of cytochalasin A on apical growth, actin cytoskeleton organization and enzyme secretion in Aspergillus nidulans. | Torralba, S., et al. 1998. Microbiology (Reading). 144 (Pt 1): 45-53. PMID: 9537763
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytochalasin A, 1 mg | sc-204705 | 1 mg | $105.00 | |||
Cytochalasin A, 5 mg | sc-204705A | 5 mg | $277.00 | |||
Cytochalasin A, 10 mg | sc-204705B | 10 mg | $456.00 |