Molecular structure of Chromone, CAS Number: 491-38-3
Chromone (CAS 491-38-3)
Alternate Names:
1-Benzopyran-4-one
Application:
Chromone is used in the study of oxidative stress as chromone skeleton compounds display antiradical properties
CAS Number:
491-38-3
Molecular Weight:
146.14
Molecular Formula:
C9H6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chromone compounds belong to a class of organic compounds closely related to benzopyrones. They are distinguished by their chromone moiety, featuring a benzopyrone ring system with a C-2 ketone group. The interaction of chromones with various molecular targets has been elucidated. These compounds have been found to modulate the activity of enzymes including c-Jun N-terminal kinase, cyclooxygenase-2, and lipoxygenase. Additionally, chromones have demonstrated the ability to modulate the activity of ion channels, such as the voltage-gated calcium channel and voltage-gated potassium channel.
Chromone (CAS 491-38-3) References
- Chromone and flavonoid alkaloids: occurrence and bioactivity. | Khadem, S. and Marles, RJ. 2011. Molecules. 17: 191-206. PMID: 22202807
- Chromone: a valid scaffold in medicinal chemistry. | Gaspar, A., et al. 2014. Chem Rev. 114: 4960-92. PMID: 24555663
- Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances. | Reis, J., et al. 2017. J Med Chem. 60: 7941-7957. PMID: 28537720
- Synthesis of Chromone-Related Pyrazole Compounds. | Santos, CMM., et al. 2017. Molecules. 22: PMID: 28981465
- Evolution of chromone-like compounds as potential antileishmanial agents, through the 21st century. | Silva, CFM., et al. 2020. Expert Opin Drug Discov. 15: 1425-1439. PMID: 32783762
- Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma. | Sugita, Y., et al. 2020. Medicines (Basel). 7: PMID: 32858984
- Chromone functionalized pyridine chemosensor for cupric ions detection. | Bhalla, P., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 264: 120279. PMID: 34438118
- Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features. | Amen, Y., et al. 2021. Molecules. 26: PMID: 34946728
- Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics. | Madhav, H., et al. 2022. RSC Med Chem. 13: 258-279. PMID: 35434628
- Advances in chromone-based reactants in the ring opening and skeletal reconstruction reaction: access to skeletally diverse salicyloylbenzene/heterocycle derivatives. | Guo, DG., et al. 2022. Org Biomol Chem. 20: 4681-4698. PMID: 35617020
- A pair of new chromone enantiomers from Xylaria nigripes. | Li, J., et al. 2022. Nat Prod Res. 1-7. PMID: 35949107
- Chromone Containing Hybrid Analogs: Synthesis and Applications in Medicinal Chemistry. | Auti, PS., et al. 2023. Chem Biodivers. e202300587. PMID: 37332056
- Chromone-2-carboxylic acids: roles of acidity and lipophilicity in drug disposition. | Smith, DA., et al. Drug Metab Rev. 16: 365-88. PMID: 3915471
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chromone, 5 g | sc-234357 | 5 g | $49.00 |