Cantharidic acid, an analog of cantharidin (CA), is a potent and selective inhibitor of PP2 (protein phosphatase (PP2A) and PP1 (protein phosphatase 1). PP2A regulates phosphorylation-dephosphorylation events and is found in plants and mammalian tissues. Studies show that it can cause biochemical changes in the mouse liver. Both okadaic acid (sc-3513), also a PP2A inhibitor, and cantharidic acid have been demonstrated to elevate levels of microtubule-bound phospho-53 in the breast cancer cell line, MCF7. Cantharidic acid does not inhibit PP2B or PP2C.
1. Graziano, M.J. and Casida, J.E. 1987. Toxicol. Lett. 37: 143-148. PMID: 2955551 2. Li, Y.M. and Casida, J.E. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 11867-11870. PMID: 1334551 3. Li, Y.M., et al. 1993. Biochem. Pharmacol. 46: 1435-1443. PMID: 8240393 4. Béghin, A., et al. 2008. Cell Cycle. 7: 3074-3082. PMID: 18818514
Soluble in DMSO (25 mg/ml), and ethanol (10 mg/ml warm). Partly miscible in water.
Store at room temperature
~407.8° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
PP2A: IC50 = 53 nM; PP1: IC50 = 0.56 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Beghin et alBeghin et al. (PubMed ID 18818514) showed that cantharidic acid-mediated inhibition of PPA2 increased mirotubule-bound phospho-p53 and reduced sensitivity to chemotherapy in breast cancer cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.