Molecular structure of Cantharidic Acid, CAS Number: 28874-45-5
Cantharidic Acid (CAS 28874-45-5)
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Application:
Cantharidic Acid is a potent and selective inhibitor of PP2A and PP1
CAS Number:
28874-45-5
Purity:
98%
Molecular Weight:
214.21
Molecular Formula:
C10H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cantharidic acid, an analog of cantharidin (CA), is a potent and selective inhibitor of PP2 (protein phosphatase (PP2A) and PP1 (protein phosphatase 1). PP2A regulates phosphorylation-dephosphorylation events and is found in plants and mammalian tissues. Studies show that it can cause biochemical changes in the mouse liver. Both okadaic acid (sc-3513), also a PP2A inhibitor, and cantharidic acid have been demonstrated to elevate levels of microtubule-bound phospho-53 in the breast cancer cell line, MCF7. Cantharidic acid does not inhibit PP2B or PP2C.
Cantharidic Acid (CAS 28874-45-5) References
- Doxorubicin-resistant LoVo adenocarcinoma cells display resistance to apoptosis induction by some but not all inhibitors of ser/thr phosphatases 1 and 2A. | Sieder, S., et al. 1999. Toxicology. 134: 109-15. PMID: 10403630
- Cantharidin-binding protein: identification as protein phosphatase 2A. | Li, YM. and Casida, JE. 1992. Proc Natl Acad Sci U S A. 89: 11867-70. PMID: 1334551
- Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line. | Béghin, A., et al. 2008. Cell Cycle. 7: 3074-82. PMID: 18818514
- Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. | Pitre, A., et al. 2012. Mol Biol Cell. 23: 1243-53. PMID: 22337773
- Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. | Xi, Y., et al. 2015. J Dent Res. 94: 320-9. PMID: 25425581
- Characterization of glutathione S-transferases from Sus scrofa, Cydia pomonella and Triticum aestivum: their responses to cantharidin. | Yang, XQ. and Zhang, YL. 2015. Enzyme Microb Technol. 69: 1-9. PMID: 25640718
- [Stability of cantharidin and cantharidic acid in Mylabris aqueous solution]. | Jiang, Y., et al. 2016. Zhongguo Zhong Yao Za Zhi. 41: 2824-2829. PMID: 28914023
- Cantharidic acid induces apoptosis through the p38 MAPK signaling pathway in human hepatocellular carcinoma. | Feng, IC., et al. 2018. Environ Toxicol. 33: 261-268. PMID: 29159945
- Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway. | Wang, SC., et al. 2018. Environ Toxicol. 33: 514-522. PMID: 29345422
- Comparison of the acute toxicity of endothal and cantharidic acid on mouse liver in vivo. | Graziano, MJ. and Casida, JE. 1987. Toxicol Lett. 37: 143-8. PMID: 2955551
- Plasmodium berghei serine/threonine protein phosphatase PP5 plays a critical role in male gamete fertility. | Zhu, X., et al. 2019. Int J Parasitol. 49: 685-695. PMID: 31202684
- AMPK activity is required for the induction of anhydrobiosis in a tardigrade Hypsibius exemplaris, and its potential up-regulator is PP2A. | Kondo, K., et al. 2019. Genes Cells. 24: 768-780. PMID: 31608545
- Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. | Chen, YC., et al. 2020. Environ Toxicol. 35: 619-627. PMID: 31916385
- Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues. | Li, YM., et al. 1993. Biochem Pharmacol. 46: 1435-43. PMID: 8240393
Inhibitor of:
PP1, PP2, and PP2A-Aα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cantharidic Acid, 10 mg | sc-201323 | 10 mg | $102.00 | |||
Cantharidic Acid, 50 mg | sc-201323A | 50 mg | $346.00 |