Cantharidic acid, an analog of cantharidin (CA), is a potent and selective inhibitor of PP2 (protein phosphatase (PP2A) and PP1 (protein phosphatase 1). PP2A regulates phosphorylation-dephosphorylation events and is found in plants and mammalian tissues. Studies show that it can cause biochemical changes in the mouse liver. Both okadaic acid (sc-3513), also a PP2A inhibitor, and cantharidic acid have been demonstrated to elevate levels of microtubule-bound phospho-53 in the breast cancer cell line, MCF7. Cantharidic acid does not inhibit PP2B or PP2C.
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Soluble in DMSO (25 mg/ml), and ethanol (10 mg/ml warm). Partly miscible in water.
Store at room temperature
407.76° C at 760 mmHg
PP2A: IC50 = 53 nM; PP1: IC50 = 0.56 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Beghin et alBeghin et al. (PubMed ID 18818514) showed that cantharidic acid-mediated inhibition of PPA2 increased mirotubule-bound phospho-p53 and reduced sensitivity to chemotherapy in breast cancer cells. -SCBT Publication Review
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