Brilliant Green (CAS 633-03-4)

Amantadine hydrochloride, a synthetic compound initially developed as an antiviral agent, has found diverse applications in scientific research, particularly in neuroscience and pharmacology. One of its primary mechanisms of action is the inhibition of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor crucial for synaptic transmission and plasticity in the central nervous system. By blocking the ion channel of the NMDA receptor, amantadine hydrochloride modulates glutamate-mediated neurotransmission, leading to downstream effects on neuronal excitability, synaptic plasticity, and neuroprotection. In research settings, amantadine hydrochloride is commonly employed as a pharmacological tool to investigate the role of NMDA receptors in various physiological and pathological processes, including learning and memory, neurodevelopmental disorders, neurodegenerative diseases, and psychiatric conditions. Furthermore, its ability to modulate dopamine neurotransmission through inhibition of dopamine reuptake and stimulation of dopamine release adds another dimension to its research applications, particularly in studies related to Parkinson′s disease, drug addiction, and mood disorders. Additionally, recent studies have explored the potential neuroprotective effects of amantadine hydrochloride in mitigating neuronal damage and inflammation associated with acute brain injuries, stroke, and neuroinflammatory disorders. Ongoing research continues to explain the precise mechanisms of action and potential of amantadine hydrochloride, offering valuable insights into neurobiology and pharmacology, with implications for the development of novel treatments for neurological and psychiatric disorders.