Date published: 2025-10-20
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[6]-Shogaol (CAS 555-66-8) - chemical structure image
Molecular structure of [6]-Shogaol, CAS Number: 555-66-8
[6]-Shogaol (CAS 555-66-8) - chemical structure image
Molecular structure of [6]-Shogaol, CAS Number: 555-66-8
Molecular structure of [6]-Shogaol, CAS Number: 555-66-8

[6]-Shogaol (CAS 555-66-8)

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Alternate Names:
1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one
Application:
[6]-Shogaol is An aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol.
CAS Number:
555-66-8
Molecular Weight:
276.37
Molecular Formula:
C17H24O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

[6]-Shogaol is a compound of significant interest in the field of nutritional biochemistry and food science research. It is one of the pungent constituents found in ginger and is studied for its influence on various biochemical pathways. Research on [6]-Shogaol often centers on its potential effects on enzymatic activities, particularly those involved in the metabolism of lipids and inflammatory mediators. [6]-Shogaol is also investigated for its impact on oxidative stress and its ability to modulate antioxidant defense mechanisms within cells. The compound is used in studies aiming to understand the molecular basis of flavor and pungency in ginger, as well as the transformation of ginger′s bioactive compounds during processing and storage. Furthermore, [6]-Shogaol is a subject in the exploration of natural compounds that affect cellular signaling pathways, an area that is pertinent to the broader understanding of nutrition and health.


[6]-Shogaol (CAS 555-66-8) References

  1. 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ.  |  Han, Q., et al. 2017. Oncotarget. 8: 42001-42006. PMID: 28410218
  2. Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis.  |  Zhang, M., et al. 2018. J Crohns Colitis. 12: 217-229. PMID: 28961808
  3. Occurrence, biological activity and metabolism of 6-shogaol.  |  Kou, X., et al. 2018. Food Funct. 9: 1310-1327. PMID: 29417118
  4. 6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.  |  Pei, XD., et al. 2021. Eur J Nutr. 60: 2781-2793. PMID: 33416981
  5. Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes.  |  Bischoff-Kont, I. and Fürst, R. 2021. Pharmaceuticals (Basel). 14: PMID: 34203813
  6. 6-Shogaol Mitigates Sepsis-Associated Hepatic Injury through Transcriptional Regulation.  |  Guo, X., et al. 2021. Nutrients. 13: PMID: 34684425
  7. 6-Shogaol Exerts a Neuroprotective Factor in Offspring after Maternal Immune Activation in Rats.  |  da Rosa, N., et al. 2022. Dev Neurosci. 44: 13-22. PMID: 34695825
  8. Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol.  |  Jiao, W., et al. 2022. Food Chem. 374: 131755. PMID: 34883426
  9. 6-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism.  |  Afzal, M., et al. 2022. ACS Omega. 7: 140-148. PMID: 35036685
  10. Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells.  |  Bischoff-Kont, I., et al. 2022. Front Pharmacol. 13: 844767. PMID: 35281937
  11. 6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway.  |  Qiu, JL., et al. 2022. Acta Biochim Pol. 69: 363-370. PMID: 35485077
  12. [6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice.  |  Kim, S., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35745645
  13. 6-Shogaol (enexasogoal) treatment improves experimental knee osteoarthritis exerting a pleiotropic effect over immune innate signalling responses in chondrocytes.  |  Gratal, P., et al. 2022. Br J Pharmacol. 179: 5089-5108. PMID: 35760458
  14. 6- shogaol suppresses AOM/DSS-mediated colorectal adenoma through its antioxidant and anti-inflammatory effects in mice.  |  Ajeigbe, OF., et al. 2022. J Food Biochem. 46: e14422. PMID: 36125935
  15. 6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer.  |  Mulati, S., et al. 2022. Cells. 11: PMID: 36429106

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Product NameCatalog #UNITPriceQtyFAVORITES

[6]-Shogaol, 10 mg

sc-473881
10 mg
$388.00
1-800-457-3801
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