Date published: 2025-10-18

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2-Methylbutyric acid (CAS 116-53-0)

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Alternate Names:
DL-2-Methylbutyric Acid
Application:
2-Methylbutyric acid is used in the synthesis of 2-methylbutyric anhydride
CAS Number:
116-53-0
Molecular Weight:
102.13
Molecular Formula:
C5H10O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methylbutyric acid is a carboxylic acid characterized by its chemical structure CH3CH2CH2COOH. This colorless and odorless liquid is soluble in water at room temperature. It serves as a precursor in the synthesis of numerous valuable compounds. Due to its diverse biochemical and physiological effects, it has become an essential component in laboratory experiments, facilitating the study of various biological processes. The scientific applications of 2-Methylbutyric acid span a wide range. Its utilization extends to the examination of fatty acid metabolism regulation, protein synthesis regulation, and cellular respiration regulation. Additionally, it contributes to the exploration of protein structure and function, gene expression regulation, and cell differentiation regulation. Notably, 2-Methylbutanoic acid induces several biochemical and physiological effects. It is recognized for inhibiting specific enzymes, including fatty acid synthase, for fatty acid synthesis. Moreover, it modulates the activity of particular transcription factors, such as NF-κB, which plays a role in gene expression regulation. Furthermore, it regulates the activity of metabolic enzymes, like acetyl-CoA carboxylase, involved in fatty acid synthesis.


2-Methylbutyric acid (CAS 116-53-0) References

  1. Identification of the leucine-to-2-methylbutyric acid catabolic pathway of Lactococcus lactis.  |  Ganesan, B., et al. 2006. Appl Environ Microbiol. 72: 4264-73. PMID: 16751541
  2. RIFM fragrance ingredient safety assessment, 2-methylbutyric acid, CAS Registry Number 116-53-0.  |  Api, AM., et al. 2019. Food Chem Toxicol. 130 Suppl 1: 110574. PMID: 31199989
  3. Isotope-Coded Chemical Derivatization Method for Highly Accurately and Sensitively Quantifying Short-Chain Fatty Acids.  |  Feng, X., et al. 2022. J Agric Food Chem. 70: 6253-6263. PMID: 35549180
  4. Effect of Bacillus species-fermented products and essential oils on growth performance, gut morphology, cecal short-chain fatty acid levels, and microbiota community in broilers.  |  Chang, WY. and Yu, YH. 2022. Poult Sci. 101: 101970. PMID: 35760005
  5. Nematicidal activity of volatile organic compounds produced by Bacillus altitudinis AMCC 1040 against Meloidogyne incognita.  |  Ye, L., et al. 2022. Arch Microbiol. 204: 521. PMID: 35879581
  6. Short-chain fatty acids profiling in biological samples from a mouse model of Sjögren's syndrome based on derivatized LC-MS/MS assay.  |  Nagatomo, R., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1210: 123432. PMID: 36063699
  7. Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial.  |  Brignardello, J., et al. 2022. Am J Clin Nutr. 116: 1368-1378. PMID: 36137188
  8. Flavor mechanism of micro-nanoparticles and correlation analysis between flavor substances in thermoultrasonic treated fishbone soup.  |  He, W., et al. 2023. Ultrason Sonochem. 93: 106299. PMID: 36652814
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methylbutyric acid, 100 g

sc-238149
100 g
$72.00