Z-Asp-2,6-dichlorobenzoyloxymethylketone CAS: 153088-73-4
MF: C20H17Cl2NO7
MW: 454.3
A broad Caspase Inhibitor.

Z-Asp-2,6-dichlorobenzoyloxymethylketone (CAS 153088-73-4)

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Z-Asp-2,6-dichlorobenzoyloxymethylketone is rated 5.0 out of 5 by 1.
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Nomes alternativos: Caspase-1 Inhibitor V
Aplicação Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor
Numero VAT: 153088-73-4
Privada: >98%
Peso Molecular: 454.3
Separar por Funcao: C20H17Cl2NO7
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-Asp-CH2-DCB), a cell permeable broad Caspase Inhibitor, prevents development of severe pulmonary hypertension and intravascular pulmonary endothelial cell growth caused by chronic hypoxia in murine models. This compound has also been shown to prevent des-ring B colchicine induced apoptosis of cells. Evaluation of Z-Asp-CH2-DCB on caspase inhibition has shown a reduced rate of cleavage of Troponin I-C, an important component of cardiac contractile apparatus. Z-Asp-2,6-dichlorobenzoyloxymethylketone is an inhibitor of caspase-3 and caspase-6.


Referencias

1. Gajate, C., et al. 2000. Cancer Res. 60: 2651-2659. PMID: 10825137
2. Taraseviciene-Stewart, L., et al. 2001. FASEB J. 15: 427-438. PMID: 11156958
3. Chandrashekhar, Y., et al. 2004. J. Am. Coll. Cardiol. 43: 295-301. PMID: 14736452

Estado físico :
Solid
envie :
Soluble in DMSO (5 mg/ml), and methanol (50 mg/ml). Insoluble in water.
Manutencao :
Store at -20° C
Ponto de fusão :
233.45° C (Predicted)
Ponto de fervura :
674.22° C at 760 mmHg (Predicted)
Densidade :
1.44 g/cm3 (Predicted)
Indice de produtos :
n20D 1.59 (Predicted)
IC50 :
Caspase-3: IC50 = 1.1 µM; Caspase-6: IC50 = 4.1 µM
Valores de pK :
pKa: 4.01 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00674885
SMILES :
C1=CC=C(C=C1)COC(=O)NC(CC(=O)O)C(=O)COC(=O)C2=C(C=CC=C2Cl)Cl

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