Molecular structure of Trihydroxyethylrutin, CAS Number: 7085-55-4
Trihydroxyethylrutin (CAS 7085-55-4)
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Alternate Names:
Trihydroxyethylrutin is also known as Troxerutin.
Application:
Trihydroxyethylrutin is a flavonoid derivative which is effective in protecting membranes from oxidative DNA damage.
CAS Number:
7085-55-4
Purity:
≥95%
Molecular Weight:
742.68
Molecular Formula:
C33H42O19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trihydroxyethylrutin is a flavanoid derivative which protects membranes from oxidative damage produced by neutrophils and γ radiation which have deleterious effects on DNA. In addition, Trihydroxyethylrutin acts as a weak inhibitor of platelet aggregation which is also delayed in the presence of the flavanoid. Studies suggest that Trihydroxyethylrutin inhibits peroxidation of lipids in tissues such as the liver and spleen, however it does not have any effect on tumor cells. Furthermore, Trihydroxyethylrutin protects the mouse liver from oxidative damage induced by D-galactose (sc-202564) by up-regulating the expression of NF-κB p65, iNOS, and COX-2.
Trihydroxyethylrutin (CAS 7085-55-4) References
- Effect of bioflavonoids (trihydroxyethylrutin and disodium flavodate) in vitro on neutrophil reactive oxygen production and phagocytic ability assessed by flow cytometry. | Wenisch, C. and Biffignandi, PM. 2001. Curr Med Res Opin. 17: 123-7. PMID: 11759181
- Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study. | Basile, M., et al. 2001. Curr Med Res Opin. 17: 256-61. PMID: 11922398
- Radioprotection of normal tissues in tumor-bearing mice by troxerutin. | Maurya, DK., et al. 2004. J Radiat Res. 45: 221-8. PMID: 15304964
- Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose. | Zhang, ZF., et al. 2009. J Agric Food Chem. 57: 7731-6. PMID: 19722705
- Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. | Vinothkumar, R., et al. 2014. Environ Toxicol Pharmacol. 37: 174-84. PMID: 24355798
- Effect of troxerutin and methionine on spin trapping of free oxy-radicals. | Blasig, IE., et al. 1988. Biomed Biochim Acta. 47: S252-5. PMID: 2907855
- Chemical modifications of imidazole-containing alkoxyamines increase C-ON bond homolysis rate: Effects on their cytotoxic properties in glioblastoma cells. | Yamasaki, T., et al. 2019. Bioorg Med Chem. 27: 1942-1951. PMID: 30975504
- Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway. | de Miranda, JAL., et al. 2020. Pharmaceuticals (Basel). 13: PMID: 31936203
- Comparison of the protective effect of various flavonoids against lipid peroxidation of erythrocyte membranes (induced by cumene hydroperoxide). | Affany, A., et al. 1987. Fundam Clin Pharmacol. 1: 451-7. PMID: 3447932
- Metabolites Profiling of Manilkara mabokeensis Aubrév Bark and Investigation of Biological Activities. | Worowounga, X., et al. 2022. Int J Anal Chem. 2022: 4066783. PMID: 35669910
- Discovery of New Microbial Collagenase Inhibitors. | Nitulescu, G., et al. 2022. Life (Basel). 12: PMID: 36556479
- [Treatment of an extensive lupus erythematosus disseminatus by trihydroxyethylrutin. (1st personal trial)]. | Lamberton, JN. 1965. Bull Soc Fr Dermatol Syphiligr. 72: 808-9. PMID: 5882714
- Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro. | Swies, J., et al. 1984. Pol J Pharmacol Pharm. 36: 455-63. PMID: 6442773
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trihydroxyethylrutin, 5 g | sc-203301 | 5 g | $30.00 | |||
Trihydroxyethylrutin, 25 g | sc-203301A | 25 g | $74.00 | |||
Trihydroxyethylrutin, 100 g | sc-203301B | 100 g | $300.00 | |||
Trihydroxyethylrutin, 1 kg | sc-203301C | 1 kg | $800.00 |