TMS is a strong, selective and competitive inhibitor of cytochrome P450 1B1, an overexpressed enzyme in particular tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. TMS inhibits cancer cell growth in vitro.
1. Nam, K.A., et al. 2001. Arch. Pharm. Res. 24: 441-445. 2. Chun, Y.J., et al. 2001. Cancer Res. 61: 8164-8170. 3. Kim, S., et al. 2002. J. Med. Chem. 45: 160-164.
Soluble in ethanol (25 mM), DMSO (100 mM), water (0.5 mg/ml at 25° C), DMF (~20 mg/ml), and methanol.
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