TFIID/TATA Binding Protein/TBP Antibody (1TBP22): sc-101550

TFIID Antibody (1TBP22) is a mouse monoclonal IgG1 antibody that detects TFIID in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). TFIID plays a crucial role in the initiation of transcription by RNA polymerase II, serving as a key component of the pre-initiation complex that assembles at the core promoter region of protein-coding genes. The TATA-binding subunit of TFIID, known as TBP, is essential for recognizing and binding to the TATA box, a conserved DNA sequence located approximately 25-30 base pairs upstream of the transcription start site. This interaction facilitates the recruitment of other transcription factors and RNA polymerase II, ultimately leading to the formation of a functional transcription complex. The highly conserved C-terminal domain of TBP, consisting of 180 amino acids, is critical for binding affinity and specificity, underscoring TFIID′s importance in regulating gene expression across various eukaryotic species. Anti-TFIID antibody (1TBP22) enables researchers to effectively study the dynamics of transcription initiation and the intricate mechanisms that govern gene regulation in diverse biological contexts.

The preferred TFIID/TATA Binding Protein/TBP antibody is TFIID/TATA Binding Protein/TBP Antibody (58C9): sc-421.