Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and release in animal models and cell culture. Talniflumate possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
1. Knight, D., 2004. Curr. Opin. Invest. Drugs. 5: 557-562. 2. Walker, N.M., et al. 2006. J. Pharmacol. Exp. Ther. 317: 275-283.
Soluble in DMSO (25 mM).
Store at -20° C
Ponto de fusão
Ponto de fervura
~534.57° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
Indice de produtos
n20D 1.63 (Predicted)
Valores de pK
pKb: 2.72 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
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