Syntaxin 1 Antibody (4E209): sc-73098

Syntaxin 1 Antibody (4E209) is a mouse monoclonal IgG1 antibody that detects Syntaxin 1 across a broad range of species through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Syntaxin 1 plays a crucial role in vesicular transport, which is vital for eukaryotic cell survival. Syntaxin 1 belongs to the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) family, essential for synaptic vesicle fusion with the plasma membrane. Syntaxin 1 interacts with v-SNAREs and t-SNAREs to form a stable SNARE complex, facilitating lipid bilayer fusion and neurotransmitter release. This interaction supports neuronal communication, hormone secretion, and membrane trafficking. Syntaxin 1 resides predominantly in presynaptic terminals of neurons, ensuring precise neurotransmitter release and influencing synaptic transmission and plasticity. Anti-Syntaxin 1 antibody (4E209) serves as an invaluable tool for researchers studying these fundamental processes in cellular communication and signaling.

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Syntaxin 1 Antibody (4E209) References:

1. Expression of vesicular monoamine transporters, synaptosomal-associated protein 25 and syntaxin1: a signature of human small cell lung carcinoma.  |  Graff, L., et al. 2001. Cancer Res. 61: 2138-44. PMID: 11280778
2. Changes in haematological parameters following captive bolt stunning in relation to the increased level of Syntaxin 1-B, a CNS marker in blood.  |  Anil, H., et al. 2002. Transfus Apher Sci. 26: 135-8. PMID: 12121070
3. Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells.  |  Arunachalam, L., et al. 2008. Mol Biol Cell. 19: 722-34. PMID: 18077557
4. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.  |  Hu, SH., et al. 2011. Proc Natl Acad Sci U S A. 108: 1040-5. PMID: 21193638
5. Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability.  |  Arancillo, M., et al. 2013. J Neurosci. 33: 16698-714. PMID: 24133272
6. TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.  |  Meng, J., et al. 2016. Sci Rep. 6: 21226. PMID: 26888187
7. MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10.  |  Pons-Vizcarra, M., et al. 2019. J Cell Sci. 132: PMID: 31719162
8. Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion.  |  Martínez-Mármol, R., et al. 2023. Front Mol Neurosci. 16: 1253954. PMID: 37829513
9. Axonal transport and targeting of the t-SNAREs SNAP-25 and syntaxin 1 in the peripheral nervous system.  |  Li, JY., et al. 1996. Eur J Cell Biol. 70: 12-22. PMID: 8738415
10. Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca(2+)- but not for guanosine 5'-[gamma-thio]triphosphate-induced secretion.  |  Martin, F., et al. 1996. Biochem J. 320 (Pt 1): 201-5. PMID: 8947488

The preferred Syntaxin 1 antibody is Syntaxin 1 Antibody (HPC-1): sc-12736.