SUGT1 Antibody (B-3): sc-398639

SUGT1 Antibody (B-3) is a mouse monoclonal IgG2a antibody that detects SUGT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SUGT1, also known as Suppressor of G2 allele of Skp1 p19 homolog, is a crucial regulator of the cell cycle, particularly important for the G1/S and G2/M transitions, ensuring proper cell division and function. SUGT1 is primarily located in the nucleus and cytoplasm, where SUGT1 plays a vital role in various cellular processes. SUGT1 contains several functional domains, including a CS domain, a SGS domain, a p23 domain, and three tetratricopeptide repeats (TPR), which facilitate interactions with other proteins. Notably, SUGT1 associates with Skp1 p19 and CUL1, components of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex, highlighting SUGT1′s involvement in protein degradation pathways. Additionally, SUGT1 is essential for the assembly of kinetochores and acts as a co-chaperone for HSP 90, underscoring SUGT1′s importance in maintaining cellular homeostasis and responding to stress. An alternative isoform, SUGT1B, arises from alternative splicing, further diversifying SUGT1′s functional roles in cellular regulation. anti-SUGT1 antibody (B-3) is an invaluable tool for researchers studying cell cycle dynamics and protein interactions in various biological contexts.

The preferred SUGT1 antibody is SUGT1 Antibody (B-10): sc-398625.