Sorting nexin (SNX) proteins are members of a large family of hydrophilic proteins that interact with a variety of receptor types, are involved in intracellular trafficking and contain a characteristic phox homology (PX) domain. SNX17, which demonstrates ubiquitous expression, contains a PX domain that shares 28% sequence identity with the PX domain of SNX1, as well as a B41 (FERM) domain. The SNX17 gene maps to chromosome 2 and is part of the cellular sorting machinery that regulates cell surface levels of LRP (lipoprotein receptor-related protein) by promoting its recycling. While the PX domain of SNX17 interacts with phosphatidylinositol-3-phosphate for membrane association, the FERM domain and the carboxyl-terminal region aid in LRP binding. Research indicates that SNX17 is localized to the limiting membrane and recycling tubules of early endosomes.
Informacoes sobre ordens
Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
SNX17 Anticorpo (D-10) | sc-166585 | 200 µg/ml | $316.00 | |||
Pacote do SNX17 (D-10): m-IgG Fc BP-HRP | sc-540125 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pacote do SNX17 (D-10): m-IgG1 BP-HRP | sc-541919 | 200 µg Ab; 20 µg BP | $354.00 | |||
SNX17 (D-10) peptídeo neutralizante | sc-166585 P | 100 µg/0.5 ml | $68.00 |