Molecular structure of (RS)-PPG, CAS Number: 120667-15-4
(RS)-PPG (CAS 120667-15-4)
Alternate Names:
(RS)-Phosphonophenylglycine
Application:
(RS)-PPG is a potent and selective group III mGluR agonist
CAS Number:
120667-15-4
Purity:
≥95%
Molecular Weight:
231.1
Molecular Formula:
C8H10NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(RS)-PPG is a potent and selective group III mGluR agonist, with a subtype specificity towards the mGlu3 receptor.
(RS)-PPG (CAS 120667-15-4) References
- Pharmacological agents acting at subtypes of metabotropic glutamate receptors. | Schoepp, DD., et al. 1999. Neuropharmacology. 38: 1431-76. PMID: 10530808
- Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity. | Taylor, DL., et al. 2003. J Neurosci. 23: 2150-60. PMID: 12657674
- Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats. | Pałucha, A., et al. 2004. Neuropharmacology. 46: 151-9. PMID: 14680755
- Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats. | Stachowicz, K., et al. 2005. Pharmacol Rep. 57: 856-60. PMID: 16382208
- Anxiolytic-like effects of group III mGlu receptor ligands in the hippocampus involve GABAA signaling. | Stachowicz, K., et al. 2006. Pharmacol Rep. 58: 820-6. PMID: 17220539
- Activation of the mGlu7 receptor elicits antidepressant-like effects in mice. | Palucha, A., et al. 2007. Psychopharmacology (Berl). 194: 555-62. PMID: 17622518
- Mood disorders: regulation by metabotropic glutamate receptors. | Pilc, A., et al. 2008. Biochem Pharmacol. 75: 997-1006. PMID: 18164691
- Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders. | Byrnes, KR., et al. 2009. Neurotherapeutics. 6: 94-107. PMID: 19110202
- Novel glutamatergic drugs for the treatment of mood disorders. | Lapidus, KA., et al. 2013. Neuropsychiatr Dis Treat. 9: 1101-12. PMID: 23976856
- Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. | Williams, CJ. and Dexter, DT. 2014. J Neurochem. 129: 4-20. PMID: 24224472
- Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. | Bigge, CF., et al. 1989. J Med Chem. 32: 1580-90. PMID: 2544728
- Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. | Masilamoni, GJ. and Smith, Y. 2018. Curr Opin Pharmacol. 38: 72-80. PMID: 29605730
- Group III metabotropic glutamate receptors as promising targets for neuroprotective therapy: Particular emphasis on the role of mGlu4 and mGlu7 receptors. | Domin, H. 2022. Pharmacol Biochem Behav. 219: 173452. PMID: 36030890
Inhibitor of:
mGLuR-8.Activator of:
mGluR-4, mGluR-6, mGluR-7, and mGluR-8a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(RS)-PPG, 5 mg | sc-202797 | 5 mg | $71.00 |