Reveromycin A CAS: 134615-37-5
MF: C36H52O11
MW: 660.8
A spiroketal antibiotic inhibitor of EGF mitogenic activity.

Reveromycin A (CAS 134615-37-5)

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Aplicação Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity
Numero VAT: 134615-37-5
Privada: >99%
Peso Molecular: 660.8
Separar por Funcao: C36H52O11
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
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Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF (epidermal growth factor). It is a G1 phase cell cycle inhibitor, selectively inhibiting IleRS (isoleucyl-tRNA synthetase). Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.


Referencias

1. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Woo J.T. et al. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4729. 2. Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity. Muguruma H. et al. Clin. Cancer Res. 2005, 11, 8822. 3. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y. et al. J. Biol. Chem. 2002, 277, 28810. 4. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. Antibiot. 1992, 45, 1414.

Aparência :
Lyophilized
Estado físico :
Solid
Derivado de :
Streptomyces sp.
envie :
Soluble in ethyl acetate, ethanol, methanol, DMF, and DMSO.
Manutencao :
Store at -20° C
Ponto de fervura :
849.02° C at 760 mmHg (Predicted)
Densidade :
1.22 g/cm3 (Predicted)
Indice de produtos :
n20D 1.56 (Predicted)
IC50 :
IleRS: IC50 = 1.97 nM (rat); IleRS: IC50 = 4.46 nM (human); NRK: EC5050 = 2.39 µM (rat)
Valores de pK :
pKa: 4.36 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00912537
SMILES :
CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O

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Reveromycin A (CAS 134615-37-5)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Reveromycin A (CAS 134615-37-5). Clique em PubMed para ver .

Citações 1 para 1 de 1 total

PMID: # 18840695  Yano, A. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 15541-15546.

Citações 1 para 1 de 1 total
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