RBP Antibody (F-12): sc-46688
- RBP Antibody (F-12) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-201 representing full length RBP of human origin
- recommended for detection of precursor and mature RBP of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RBP Antibody (F-12) for WB and IHC(P) applications. These reagents are now offered in bundles with RBP Antibody (F-12) (see ordering information below).
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RBP Antibody (F-12) is a mouse monoclonal IgG1 antibody that detects retinol-binding protein (RBP) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RBP is a crucial transport protein that plays a significant role in delivering retinol (Vitamin A) from the liver to peripheral tissues, ensuring cells receive this essential nutrient for various biological functions, including vision, immune response, and cellular growth. RBP′s location in the bloodstream is particularly important, as RBP binds to transthyretin (TTR) to form a stable complex that prevents renal filtration, thereby maintaining adequate retinol levels in circulation. This interaction not only protects RBP from degradation but also serves as a diagnostic marker for vitamin A deficiency, as the molar ratio of RBP to TTR can indicate nutritional status. Furthermore, emerging research has linked elevated RBP levels in adipose tissue to insulin resistance, suggesting RBP may have a role in the pathogenesis of metabolic disorders such as type 2 diabetes and obesity. Anti-RBP antibody (F-12) is an invaluable tool for researchers investigating the multifaceted roles of RBP in health and disease.
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RBP Antibody (F-12) References:
- Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin. | Zanotti, G. and Berni, R. 2004. Vitam Horm. 69: 271-95. PMID: 15196886
- Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. | Mills, JP., et al. 2008. Exp Biol Med (Maywood). 233: 1255-61. PMID: 18641048
- Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex. | Hyung, SJ., et al. 2010. ACS Chem Biol. 5: 1137-46. PMID: 20845945
- Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells. | Choi, S., et al. 2012. Biochem Biophys Res Commun. 418: 191-7. PMID: 22266308
- Retinol-binding protein: the serum transport protein for vitamin A. | Blaner, WS. 1989. Endocr Rev. 10: 308-16. PMID: 2550213
- The effect of retinol binding protein on the proteome of C2C12 muscle cells. | Young, PA., et al. 2016. Diabetes Metab Res Rev. 32: 379-90. PMID: 26556762
- The retinol-binding protein receptor STRA6 regulates diurnal insulin responses. | Gliniak, CM., et al. 2017. J Biol Chem. 292: 15080-15093. PMID: 28733465
- Familial retinol-binding-protein deficiency. | Matsuo, T., et al. 1987. Lancet. 2: 402-3. PMID: 2886863
- Retinol-binding protein from human urine and its interaction with retinol and prealbumin. | Fex, G. and Hansson, B. 1979. Eur J Biochem. 94: 307-13. PMID: 571335
- Cellular retinol-binding protein. | Bashor, MM. and Chytil, F. 1975. Biochim Biophys Acta. 411: 87-96. PMID: 810177
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RBP Antibody (F-12) | sc-46688 | 200 µg/ml | $322.00 | |||
RBP Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-536791 | 200 µg Ab; 10 µg BP | $361.00 | |||
RBP Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-533955 | 200 µg Ab; 40 µg BP | $361.00 | |||
RBP Antibody (F-12): m-IgG1 BP-HRP Bundle | sc-544820 | 200 µg Ab; 20 µg BP | $361.00 |