PYK2 Antibody (Y-129): sc-100379

PYK2 Antibody (Y-129) is a mouse monoclonal IgG2b antibody that detects PYK2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PYK2, also known as proline-rich tyrosine kinase 2, plays a crucial role in cellular signaling, particularly in the central nervous system, where PYK2 is highly expressed. PYK2 is involved in the modulation of ion channel function and the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, which are essential for various cellular processes, including growth, differentiation, and response to stress. The activation of PYK2 occurs rapidly in response to stimuli that elevate intracellular calcium levels, as well as through the action of phorbol esters that activate protein kinase C (PKC) family members. Notably, PYK2 undergoes significant post-translational modifications, including phosphorylation on tyrosine residues, which are critical for function and regulation. These modifications not only enhance kinase activity but also facilitate interactions with other signaling proteins, thereby amplifying the cellular response to external signals. Anti-PYK2 antibody (Y-129) is an invaluable tool for researchers aiming to explore the intricate signaling pathways involving PYK2 and its role in various physiological and pathological processes.

The preferred p-PYK2 antibody is p-PYK2 Antibody (13.Tyr 402): sc-293142.