Pitavastatin Calcium CAS: 147526-32-7
MF: C50H46CaF2N2O8
MW: 880.98
A competitive inhibitor of HMG-CoA reductase.

Pitavastatin Calcium (CAS 147526-32-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 121ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Pitavastatin Calcium is rated 5.0 out of 5 by 2.
loading
5
2
4
0
3
0
2
0
1
0
Nomes alternativos: Pitavastatin hemicalcium; Nisvastatin
Aplicação Pitavastatin Calcium is a competitive inhibitor of HMG-CoA reductase
Numero VAT: 147526-32-7
Privada: ≥98%
Peso Molecular: 880.98
Separar por Funcao: C50H46CaF2N2O8
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
loading

Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.


Referencias

1. Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
2. Terata, Y., et al. 2003. Pharmacology. 68: 169-176. PMID: 12837970
3. Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-263. PMID: 15380447
4. Takayama, T., et al. 2004. Circ. J. 68: 1067-1075. PMID: 15502390

Aparência :
Powder
Estado físico :
Solid
envie :
Soluble in DMSO (100 mMl), water (<1 mg/ml), and ethanol (<1 mg/ml).
Manutencao :
Store at room temperature
Ponto de fervura :
692° C at 760 mmHg
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
PubChem CID :
SMILES :
O[[email protected]](/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1)C[[email protected]@H](O)CC(=O)O[Ca]OC(=O)C[[email protected]](O)C[[email protected]](O)/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1

Baixar SDS (MSDS)

Certificado de Análise

É necessário o Adobe Acrobat Reader para visualizar corretamente,
imprimir e comentar os documentos PDF

Pitavastatin Calcium (CAS 147526-32-7)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Pitavastatin Calcium (CAS 147526-32-7). Clique em PubMed para ver .

Citações 1 para 7 de 7 total

PMID: # 25993292  Yoshimura, K. et al. 2015. Int J Mol Sci. 16: 11213-28.

PMID: # 24671957  Chang, JH. et al. 2014. Drug Metab. Dispos. 42: 1067-73.

PMID: # 23750830  Chang, JH. et al. 2013. Mol. Pharm. 10: 3067-75.

PMID: # 23564645  Zhang, X. et al. 2013. Toxicological sciences : an official journal of the Society of Toxicology. 134: 73-82.

PMID: # 31772607  Cardiovasc Ther. 2019: 2549432.

PMID: # 31527323  J. Atheroscler. Thromb. 27: 429-440.

PMID: # 32435188  Front Pharmacol. 469.

Citações 1 para 7 de 7 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 115ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;