Per2 Antibody (19-J6): sc-101105
- Per2 Antibody (19-J6) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 50 µg/0.5 ml
- raised against recombinant Per2 of human origin
- recommended for detection of Per2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Per2 Antibody (19-J6). This work is in progress.
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Per2 Antibody (19-J6) is a mouse monoclonal IgG2b antibody that detects Per2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Per2 (19-J6) antibody plays a crucial role in studying the regulation of circadian rhythms, as Per2 acts as a key component of the molecular clock that governs physiological processes such as sleep-wake cycles and hormonal fluctuations. Located primarily in the suprachiasmatic nucleus (SCN) of the brain, Per2 is essential for maintaining the timing of these biological rhythms, and Per2 expression is tightly regulated by light exposure. Notably, Per2 interacts with other period proteins, including Per1 and Per3, to form a feedback loop that stabilizes circadian oscillations. Disruptions in Per2 function can lead to altered circadian rhythms, which have been linked to various health issues, including sleep disorders and metabolic syndromes. anti-Per2 antibody (19-J6) serves as an invaluable tool for researchers studying the intricate mechanisms of circadian biology and its implications for human health.
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Per2 Antibody (19-J6) References:
- Biochemical characterization of PER-2 and genetic environment of blaPER-2. | Power, P., et al. 2007. Antimicrob Agents Chemother. 51: 2359-65. PMID: 17438050
- SIRT1 regulates circadian clock gene expression through PER2 deacetylation. | Asher, G., et al. 2008. Cell. 134: 317-28. PMID: 18662546
- NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. | Levine, DC., et al. 2020. Mol Cell. 78: 835-849.e7. PMID: 32369735
- Per1/Per2-Igf2 axis-mediated circadian regulation of myogenic differentiation. | Katoku-Kikyo, N., et al. 2021. J Cell Biol. 220: PMID: 34009269
- PER2-mediated ameloblast differentiation via PPARγ/AKT1/β-catenin axis. | Huang, W., et al. 2021. Int J Oral Sci. 13: 16. PMID: 34011974
- PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop. | Alexandrou, AT., et al. 2022. iScience. 25: 105546. PMID: 36465103
- PER2 integrates circadian disruption and pituitary tumorigenesis. | Guo, L., et al. 2023. Theranostics. 13: 2657-2672. PMID: 37215573
- PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-κB pathway and PD-L1 expression. | Zhang, Z., et al. 2023. J Immunother Cancer. 11: PMID: 37914384
- Importance of Per2 in cardiac mitochondrial protection during stress. | Bhaskara, M., et al. 2024. Sci Rep. 14: 1290. PMID: 38221535
- Insights into the activity of cefiderocol against PER-2 producing Enterobacterales. | Ruggiero, M., et al. 2024. Antimicrob Agents Chemother. 68: e0172023. PMID: 38690895
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Per2 Antibody (19-J6) | sc-101105 | 50 µg/0.5 ml | $339.00 |