NPC 15199 (CAS 35661-60-0)
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NPC 15199 is an N-(9-fluorenylmethoxycarbonyl)-protected leucine compound that demonstrates antiinflammatory effects. NPC 15199 and other N-(9-fluorenylmethoxycarbonyl)-protected amino acids are demonstrated to block recruitment of neutrophils into inflammatory lesions and to inhibit T-cell activation in vitro, and are classified as leumedins. NPC 15199 is described to act as a chemically distinct ligand and modulator of PPARgamma (peroxisome proliferator-activated receptor gamma). NPC 15199 is demonstrated to increase intracellular Ca2+ and to mobilize Ca2+ stores in human bladder female transitional cancer (BFTC) cells. NPC 15199 is also demonstrated to prevent mucosal injury in a model of ileitis in guinea pigs.
NPC 15199 (CAS 35661-60-0) References
- NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. | Jan, CR., et al. 2000. Chin J Physiol. 43: 29-33. PMID: 10857466
- A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. | Rocchi, S., et al. 2001. Mol Cell. 8: 737-47. PMID: 11684010
- Effect of NPC-14686 (Fmoc-L-homophenylalanine) on intracellular Ca2+ levels in human hepatoma cells. | Jan, CR., et al. 2003. Life Sci. 72: 2571-80. PMID: 12672503
- Effect of NPC-15199 on Ca2+ levels in renal tubular cells. | Jan, CR., et al. 2002. Chin J Physiol. 45: 117-22. PMID: 12817714
- Small molecule hydrogels based on a class of antiinflammatory agents. | Yang, Z., et al. 2004. Chem Commun (Camb). 208-9. PMID: 14737552
- N-(fluorenyl-9-methoxycarbonyl) amino acids, a class of antiinflammatory agents with a different mechanism of action. | Burch, RM., et al. 1991. Proc Natl Acad Sci U S A. 88: 355-9. PMID: 1824872
- Anti-inflammatory agents and substance P depletion in experimental ileitis. | Miller, MJ., et al. 1993. Mediators Inflamm. 2: 293-7. PMID: 18475536
- Controlled drug release through a plasma polymerized tetramethylcyclo-tetrasiloxane coating barrier. | Osaki, S., et al. 2012. J Biomater Sci Polym Ed. 23: 483-96. PMID: 21294969
- Enzymatic formation of a novel cell-adhesive hydrogel based on small peptides with a laterally grafted l-3,4-dihydroxyphenylalanine group. | Xu, JX., et al. 2014. Nanoscale. 6: 1277-80. PMID: 24322882
- Effect of NPC15199 on [Ca²⁺]i and viability in SCM1 human gastric cancer cells. | Cheng, HH., et al. 2016. Chin J Physiol. 59: 268-275. PMID: 27604137
- Plasma treatment as an efficient tool for controlled drug release from polymeric materials: A review. | Petlin, DG., et al. 2017. J Control Release. 266: 57-74. PMID: 28935595
- Investigations of Anti-Inflammatory Activity of a Peptide-Based Hydrogel Using Rat Air Pouch Model. | Gavel, PK., et al. 2019. ACS Appl Mater Interfaces. 11: 2849-2859. PMID: 30589529
- Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199). | Miller, MJ., et al. 1993. J Pharmacol Exp Ther. 266: 468-72. PMID: 8392562
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPC 15199, 250 mg | sc-202741 | 250 mg | $41.00 |