Nidogen Antibody (331F3): sc-47773
- Nidogen Antibody (331F3) is a mouse monoclonal IgM κ, cited in 3 publications, provided at 200 µg/ml
- raised against purified preparation of Nidogen of bovine origin
- recommended for detection of Nidogen of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including bovine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nidogen Antibody (331F3). This work is in progress.
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Nidogen Antibody (331F3) is a mouse monoclonal IgM antibody that detects Nidogen in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Nidogen, also known as Entactin, is a crucial sulfated glycoprotein that plays a significant role in the formation and stability of basement membranes, which are essential for tissue architecture and cellular organization. Nidogen serves as a vital link between key extracellular matrix components, specifically Laminin 1 and Collagen Type IV, facilitating their assembly into a functional matrix. Nidogen′s importance extends beyond structural support; anti-Nidogen antibody (331F3) helps reveal involvement in various cellular processes, including cell adhesion and signaling, particularly in mesenchymal peritubular and myoepithelial cells, where Nidogen influences cell behavior in an autocrine manner. Nidogen is highly conserved across species, and Nidogen expression is tightly regulated during embryonic and fetal development, being present exclusively in fully developed basement membranes of the ectoderm. This specificity underscores Nidogen′s critical role in developmental biology and tissue integrity, making Nidogen (331F3) monoclonal antibody an invaluable tool for researchers studying extracellular matrix dynamics and related cellular functions.
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Nidogen Antibody (331F3) References:
- Nidogen is a prosurvival and promigratory factor for adult Schwann cells. | Lee, HK., et al. 2007. J Neurochem. 102: 686-98. PMID: 17437540
- Nidogen plays a role in the regenerative axon growth of adult sensory neurons through Schwann cells. | Lee, HK., et al. 2009. J Korean Med Sci. 24: 654-9. PMID: 19654948
- Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution. | Patel, TR., et al. 2014. Matrix Biol. 33: 60-7. PMID: 23948589
- Distribution of nidogen in the murine eye and ocular phenotype of the nidogen-1 knockout mouse. | May, CA. 2012. ISRN Ophthalmol. 2012: 378641. PMID: 24555126
- Binding of nidogen and the laminin-nidogen complex to basement membrane collagen type IV. | Aumailley, M., et al. 1989. Eur J Biochem. 184: 241-8. PMID: 2506015
- Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells. | Dziadek, M. and Timpl, R. 1985. Dev Biol. 111: 372-82. PMID: 2995165
- Nidogen: a new, self-aggregating basement membrane protein. | Timpl, R., et al. 1983. Eur J Biochem. 137: 455-65. PMID: 6420150
- Role of mesenchymal nidogen for epithelial morphogenesis in vitro. | Ekblom, P., et al. 1994. Development. 120: 2003-14. PMID: 7925005
- Influence of nidogen complexed or not with laminin on attachment, spreading, and albumin and laminin B2 mRNA levels of rat hepatocytes. | Levavasseur, F., et al. 1994. J Cell Physiol. 161: 257-66. PMID: 7962110
- Nidogen mediates the formation of ternary complexes of basement membrane components. | Aumailley, M., et al. 1993. Kidney Int. 43: 7-12. PMID: 8433572
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nidogen Antibody (331F3) | sc-47773 | 200 µg/ml | $322.00 |