NFRκB Antibody (445C4a): sc-81106
- NFRκB Antibody (445C4a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of NFRκB of human origin
- recommended for detection of NFRκB of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NFRκB Antibody (445C4a). This work is in progress.
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NFRκB Antibody (445C4a) is a mouse monoclonal IgG1 antibody that detects NFRκB in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). NFRκB, also known as nuclear factor related to kappa-B-binding protein, plays a crucial role in regulating gene expression, particularly in the context of immune responses and cell signaling. NFRκB is primarily located in the nucleus, where NFRκB binds to specific DNA sequences to modulate the transcription of genes involved in T-cell activation, including the interleukin-2 receptor alpha-chain. NFRκB′s ability to influence IL-2Rα expression is vital for proper T-cell function, as NFRκB is a key factor in the immune response, promoting cell proliferation and survival. Notably, NFRκB exists in three isoforms due to alternative splicing, which allows for diverse regulatory functions in various tissues, including the brain, liver, spleen, testis, and thymus. NFRκB expression is notably increased in acute myeloid leukemia, indicating NFRκB′s potential involvement in cancer development and progression. With NFRκB′s significant role in immune regulation and potential implications in cancer biology, anti-NFRκB antibody (445C4a) serves as an essential tool for researchers studying these critical pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFRκB Antibody (445C4a) | sc-81106 | 100 µg/ml | $339.00 |